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Update on surveillance in Von Hippel-Lindau disease

Von Hippel-Lindau disease (VHL) is a genetic condition characterized by a high lifetime risk for tumors and cysts throughout the body, including the central nervous system, visual-auditory systems, and intra-abdominal organs. This neoplasia leads to significant morbidity and potential mortality in a...

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Main Authors: Rednam, Surya (Author) , Becktell, Kerri D. (Author) , Villani, Anita (Author) , Brodeur, Garrett M. (Author) , States, Lisa J. (Author) , Doria, Andrea S. (Author) , Kamihara, Junne (Author) , Schneider, Kami Wolfe (Author) , Voss, Stephan D. (Author) , Widjaja, Elysa (Author) , Zelley, Kristin (Author) , Nakano, Yoshiko (Author) , Pajtler, Kristian Wilfried (Author) , Achatz, Maria Isabel (Author) , Malkin, David (Author) , Diller, Lisa R. (Author) , Gallinger, Bailey (Author) , Tamura, Chieko (Author) , Wasserman, Jonathan D. (Author)
Format: Article (Journal)
Language:English
Published: 15 June 2025
In: Clinical cancer research
Year: 2025, Volume: 31, Issue: 12, Pages: 2271-2277
ISSN:1557-3265
DOI:10.1158/1078-0432.CCR-24-3525
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/1078-0432.CCR-24-3525
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Author Notes:Surya P. Rednam, Kerri D. Becktell, Anita Villani, Garrett M. Brodeur, Lisa J. States, Andrea S. Doria, Junne Kamihara, Kami Wolfe Schneider, Stephan D. Voss, Elysa Widjaja, Kristin Zelley, Yoshiko Nakano, Kristian W. Pajtler, Maria Isabel Achatz, David Malkin, Lisa R. Diller, Bailey Gallinger, Chieko Tamura, and Jonathan D. Wasserman
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Summary:Von Hippel-Lindau disease (VHL) is a genetic condition characterized by a high lifetime risk for tumors and cysts throughout the body, including the central nervous system, visual-auditory systems, and intra-abdominal organs. This neoplasia leads to significant morbidity and potential mortality in affected individuals. Tumor surveillance enables early intervention and leads to improved clinical outcomes. Since the 2017 publication of VHL tumor surveillance recommendations from the inaugural American Association for Cancer Research Childhood Cancer Predisposition Workshop, several other groups have proposed alternative consensus surveillance recommendations. Although these screening paradigms share some common elements, they also deviate from each other in some substantial ways. Clinical data continue to accrue in VHL, allowing the condition to be better characterized. Furthermore, surgical techniques have improved over time, and the option of targeted medical therapy has emerged for individuals with VHL. It is critical that surveillance strategies continue to be refined. In this perspective, we provide an up-to-date clinical overview of VHL, describe recently proposed tumor screening regimens, and finally present our updated consensus tumor surveillance recommendations during childhood and adolescence from the 2023 American Association for Cancer Research Childhood Cancer Predisposition Workshop.
Item Description:Veröffentlicht: 13. Juni 2025
Gesehen am 29.10.2025
Physical Description:Online Resource
ISSN:1557-3265
DOI:10.1158/1078-0432.CCR-24-3525

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