Cover Image

Cardiovascular inflammaging: mechanisms, consequences, and therapeutic perspectives

Both aging and systemic inflammation are major risk factors for cardiovascular disease. This review summarizes the interrelationship of aging and inflammation—known as inflammaging—and the consequences for cardiovascular health. We discuss mechanisms including epigenetic modification, mitochondrial...

Full description

Saved in:
Bibliographic Details
Main Authors: Spray, Luke (Author) , Richardson, Gavin (Author) , Haendeler, Judith (Author) , Altschmied, Joachim (Author) , Rumampouw, Valencia (Author) , Wallis, Sienna B. (Author) , Georgiopoulos, Georgios (Author) , White, Stephen (Author) , Unsworth, Amanda (Author) , Stellos, Konstantinos (Author) , Tual-Chalot, Simon (Author) , Spyridopoulos, Ioakim (Author)
Format: Article (Journal)
Language:English
Published: 16 September 2025
In: Cell reports. Medicine
Year: 2025, Volume: 6, Issue: 9, Pages: 1-18
ISSN:2666-3791
DOI:10.1016/j.xcrm.2025.102264
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.xcrm.2025.102264
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S2666379125003374
Get full text
Author Notes:Luke Spray, Gavin Richardson, Judith Haendeler, Joachim Altschmied, Valencia Rumampouw, Sienna B. Wallis, Georgios Georgiopoulos, Stephen White, Amanda Unsworth, Konstantinos Stellos, Simon Tual-Chalot and Ioakim Spyridopoulos
Description
Summary:Both aging and systemic inflammation are major risk factors for cardiovascular disease. This review summarizes the interrelationship of aging and inflammation—known as inflammaging—and the consequences for cardiovascular health. We discuss mechanisms including epigenetic modification, mitochondrial dysfunction, cellular senescence, and gut dysbiosis, many of which are themselves interrelated. Increasing understanding of inflammaging provides an array of biomarkers, some of which are now recommended in international guidelines. We also discuss therapeutic strategies aiming to modify the process of inflammaging and improve cardiovascular disease outcomes, either with immunomodulating agents or with therapies targeted at specific mechanisms, such as senolytics, telomerase activators, and pre- and probiotic supplementation. We conclude that inflammaging is a key part of cardiovascular aging and provides encouraging opportunities for new therapies.
Item Description:Online verfügbar: 8. August 2025, Artikelversion: 16. September 2025
Gesehen am 29.10.2025
Physical Description:Online Resource
ISSN:2666-3791
DOI:10.1016/j.xcrm.2025.102264

Similar Items