Choroid plexus: insights from distinct epithelial cellular components
The choroid plexus (ChP) serves as a vital interface between blood and cerebrospinal fluid (CSF), playing a pivotal role in central nervous system (CNS) development and communication with the body. This review mainly summarizes how the ChP epithelial cells respond to physiological and pathological s...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
August 2025
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| In: |
Current opinion in neurobiology
Year: 2025, Volume: 93, Pages: 1-8 |
| ISSN: | 1873-6882 |
| DOI: | 10.1016/j.conb.2025.103028 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.conb.2025.103028 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0959438825000595 
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| Author Notes: | Valentina Scarpetta, Kim Hoa Ho, Marleen Trapp and Annarita Patrizi |
| Summary: | The choroid plexus (ChP) serves as a vital interface between blood and cerebrospinal fluid (CSF), playing a pivotal role in central nervous system (CNS) development and communication with the body. This review mainly summarizes how the ChP epithelial cells respond to physiological and pathological stimuli, emphasizing the role of distinct organelles and key molecular signaling pathways. Additionally, we discuss the roles of ChP cilia, an evolutionary conserved organelle whose function is still under investigation. Understanding these processes is essential for elucidating how ChP function modulates intrinsic and extrinsic stimuli, which are crucial for maintaining CNS and body homeostasis. |
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| Item Description: | Online verfügbar: 22. April 2025 Gesehen am 29.10.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1873-6882 |
| DOI: | 10.1016/j.conb.2025.103028 |