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Comparison of prognostication by IPSS-M, IPSS-R and AIPSS-MDS in the context of limited availability of molecular data in daily clinical practice

The IPSS-M was developed to revolutionize the prediction of MDS patients’ survival by incorporating molecular data. To compensate for lack of access to molecular analyses, the AIPSS-MDS, a supervised machine learning algorithm exclusively based on clinical and cytogenetic data, was developed by the...

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Main Authors: Schulz, Felicitas (Author) , Kellersmann, Carolin (Author) , Betz, Beate (Author) , Hildebrandt, Barbara (Author) , Kasprzak, Annika (Author) , Strupp, Corinna (Author) , Thol, Felicitas (Author) , Heuser, Michael (Author) , Ganster, Christina (Author) , Beier, Fabian (Author) , Sockel, Katja (Author) , Hofmann, Wolf-Karsten (Author) , Kuendgen, Andrea (Author) , Jaeger, Paul (Author) , Pfeilstoecker, Michael (Author) , Lauseker, Michael (Author) , Dietrich, Sascha (Author) , Gattermann, Nobert (Author) , Nachtkamp, Kathrin (Author) , Haase, Detlef (Author) , Germing, Ulrich (Author)
Format: Article (Journal)
Language:English
Published: September 2025
In: Annals of hematology
Year: 2025, Volume: 104, Issue: 9, Pages: 4531-4538
ISSN:1432-0584
DOI:10.1007/s00277-025-06570-0
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00277-025-06570-0
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Author Notes:Felicitas Schulz, Carolin Kellersmann, Beate Betz, Barbara Hildebrandt, Annika Kasprzak, Corinna Strupp, Felicitas Thol, Michael Heuser, Christina Ganster, Fabian Beier, Katja Sockel, Wolf-Karsten Hofmann, Andrea Kuendgen, Paul Jaeger, Michael Pfeilstoecker, Michael Lauseker, Sascha Dietrich, Nobert Gattermann, Kathrin Nachtkamp, Detlef Haase, Ulrich Germing
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Summary:The IPSS-M was developed to revolutionize the prediction of MDS patients’ survival by incorporating molecular data. To compensate for lack of access to molecular analyses, the AIPSS-MDS, a supervised machine learning algorithm exclusively based on clinical and cytogenetic data, was developed by the Spanish MDS Group. We used data of the Düsseldorf MDS Registry and included 207 of more than 8500 registry patients whose IPSS-M-requested complete molecular data were known to compare and validate prognostication regarding OS and LFS of the IPSS-M, IPSS-R and AIPSS-MDS. All three tools reliably prognosticated median OS of patients even in a comparatively small patient cohort. The IPSS-M provided the most accurate prediction of median OS while the frequent lack of molecular data persists as an obstacle in daily clinical practice. Due to these circumstances, the IPSS-R remains the prognostication tool with the widest applicability. Based on our data, prognostication using the AIPSS-MDS is also feasible but less precise.
Item Description:Online veröffentlicht: 6. September 2025
Gesehen am 30.10.2025
Physical Description:Online Resource
ISSN:1432-0584
DOI:10.1007/s00277-025-06570-0

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