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Efficacy and safety of the activin signalling inhibitor, sotatercept, in a pooled analysis of PULSAR and STELLAR studies

GRAPHICAL ABSTRACT Overview of the study. # : p<0.001 for comparison of sotatercept with placebo on the basis of aligned-rank stratified Wilcoxon test, stratified according to randomisation factors of background therapy (monotherapy or dual therapy versus triple therapy) and baseline World Health...

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Main Authors: Höper, Marius (Author) , Gomberg-Maitland, Mardi (Author) , Badesch, David B. (Author) , Gibbs, J. Simon R. (Author) , Grünig, Ekkehard (Author) , Kopeć, Grzegorz (Author) , McLaughlin, Vallerie V. (Author) , Meyer, Gisela (Author) , Olsson, Karen M. (Author) , Preston, Ioana R. (Author) , Rosenkranz, Stephan (Author) , Souza, Rogerio (Author) , Waxman, Aaron B. (Author) , Perchenet, Loïc (Author) , Strait, James (Author) , Xing, Aiwen (Author) , Manimaran, Solaiappan (Author) , Wang, Xuelong (Author) , Miller, Barry (Author) , Cornell, Alexandra G. (Author) , Pena, Janethe de Oliveira (Author) , Ghofrani, H. Ardeschir (Author) , Humbert, Marc (Author)
Format: Article (Journal)
Language:English
Published: 6 May 2025
In: European clinical respiratory journal
Year: 2025, Volume: 65, Issue: 5, Pages: 1-15
ISSN:2001-8525
DOI:10.1183/13993003.01424-2024
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1183/13993003.01424-2024
Verlag, kostenfrei, Volltext: https://publications.ersnet.org/content/erj/65/5/2401424
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Author Notes:Marius M. Hoeper, Mardi Gomberg-Maitland, David B. Badesch, J. Simon R. Gibbs, Ekkehard Grünig, Grzegorz Kopeć, Vallerie V. McLaughlin, Gisela Meyer, Karen M. Olsson, Ioana R. Preston, Stephan Rosenkranz, Rogerio Souza, Aaron B. Waxman, Loïc Perchenet, James Strait, Aiwen Xing, Solaiappan Manimaran, Xuelong Wang, Barry Miller, Alexandra G. Cornell, Janethe de Oliveira Pena, H. Ardeschir Ghofrani and Marc Humbert
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Summary:GRAPHICAL ABSTRACT Overview of the study. # : p<0.001 for comparison of sotatercept with placebo on the basis of aligned-rank stratified Wilcoxon test, stratified according to randomisation factors of background therapy (monotherapy or dual therapy versus triple therapy) and baseline World Health Organization functional class (WHO FC) (II versus III); ¶ : p<0.001 for comparison of sotatercept with placebo on basis of a Cochran–Mantel–Haenszel method, stratified according to randomisation factors. 6MWD: 6-min walk distance; PAH: pulmonary arterial hypertension; PVR: pulmonary vascular resistance.
Item Description:Gesehen am 04.11.2025
Physical Description:Online Resource
ISSN:2001-8525
DOI:10.1183/13993003.01424-2024

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