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Group 2 innate lymphoid cells drive inhibitory synapse formation with lasting effects on learning and memory

The immune system provides multiple layers of protection that extend beyond conventional pathogen defense, including context-dependent modulation of behavior. However, the mechanisms driving these immune-mediated behavioral modifications remain incompletely understood. Here, we demonstrate that grou...

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Main Authors: Steffen, Johannes (Author) , Deshpande, Divija (Author) , Düsedau, Henning Peter (Author) , Schmitz, Janna (Author) , Figueiredo, Caio Andreeta (Author) , Velleman, Laura (Author) , Pitzer, Claudia (Author) , Klose, Christoph Siegfried Niki (Author) , Dunay, Ildikò Rita (Author)
Format: Article (Journal)
Language:English
Published: 23 June 2025
In: Journal of neuroinflammation
Year: 2025, Volume: 22, Pages: 1-10
ISSN:1742-2094
DOI:10.1186/s12974-025-03485-5
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12974-025-03485-5
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Author Notes:Johannes Steffen, Divija Deshpande, Henning Peter Düsedau, Janna Schmitz, Caio Andreeta Figueiredo, Laura Velleman, Claudia Pitzer, Christoph S.N. Klose and Ildiko R. Dunay
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Summary:The immune system provides multiple layers of protection that extend beyond conventional pathogen defense, including context-dependent modulation of behavior. However, the mechanisms driving these immune-mediated behavioral modifications remain incompletely understood. Here, we demonstrate that group 2 innate lymphoid cells (ILC2s) shape hippocampal synaptic development during early postnatal stages, with lasting effects on adult behavior, learning, and memory.
Item Description:Gesehen am: 08.12.2025
Physical Description:Online Resource
ISSN:1742-2094
DOI:10.1186/s12974-025-03485-5

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