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Group 2 innate lymphoid cells drive inhibitory synapse formation with lasting effects on learning and memory

The immune system provides multiple layers of protection that extend beyond conventional pathogen defense, including context-dependent modulation of behavior. However, the mechanisms driving these immune-mediated behavioral modifications remain incompletely understood. Here, we demonstrate that grou...

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Hauptverfasser: Steffen, Johannes (VerfasserIn) , Deshpande, Divija (VerfasserIn) , Düsedau, Henning Peter (VerfasserIn) , Schmitz, Janna (VerfasserIn) , Figueiredo, Caio Andreeta (VerfasserIn) , Velleman, Laura (VerfasserIn) , Pitzer, Claudia (VerfasserIn) , Klose, Christoph Siegfried Niki (VerfasserIn) , Dunay, Ildikò Rita (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 23 June 2025
In: Journal of neuroinflammation
Year: 2025, Jahrgang: 22, Pages: 1-10
ISSN:1742-2094
DOI:10.1186/s12974-025-03485-5
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12974-025-03485-5
Volltext
Verfasserangaben:Johannes Steffen, Divija Deshpande, Henning Peter Düsedau, Janna Schmitz, Caio Andreeta Figueiredo, Laura Velleman, Claudia Pitzer, Christoph S.N. Klose and Ildiko R. Dunay
Beschreibung
Zusammenfassung:The immune system provides multiple layers of protection that extend beyond conventional pathogen defense, including context-dependent modulation of behavior. However, the mechanisms driving these immune-mediated behavioral modifications remain incompletely understood. Here, we demonstrate that group 2 innate lymphoid cells (ILC2s) shape hippocampal synaptic development during early postnatal stages, with lasting effects on adult behavior, learning, and memory.
Beschreibung:Gesehen am: 08.12.2025
Beschreibung:Online Resource
ISSN:1742-2094
DOI:10.1186/s12974-025-03485-5

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