Group 2 innate lymphoid cells drive inhibitory synapse formation with lasting effects on learning and memory
The immune system provides multiple layers of protection that extend beyond conventional pathogen defense, including context-dependent modulation of behavior. However, the mechanisms driving these immune-mediated behavioral modifications remain incompletely understood. Here, we demonstrate that grou...
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
23 June 2025
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| In: |
Journal of neuroinflammation
Year: 2025, Jahrgang: 22, Pages: 1-10 |
| ISSN: | 1742-2094 |
| DOI: | 10.1186/s12974-025-03485-5 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12974-025-03485-5
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| Verfasserangaben: | Johannes Steffen, Divija Deshpande, Henning Peter Düsedau, Janna Schmitz, Caio Andreeta Figueiredo, Laura Velleman, Claudia Pitzer, Christoph S.N. Klose and Ildiko R. Dunay |
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| 520 | |a The immune system provides multiple layers of protection that extend beyond conventional pathogen defense, including context-dependent modulation of behavior. However, the mechanisms driving these immune-mediated behavioral modifications remain incompletely understood. Here, we demonstrate that group 2 innate lymphoid cells (ILC2s) shape hippocampal synaptic development during early postnatal stages, with lasting effects on adult behavior, learning, and memory. | ||
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