Cover Image

Molecular mediators of the cardiacbenefits of exercise

Exercise exerts myriad cardiovascular benefits and protects against most forms of cardiovascular disease. While extensive epidemiological evidence supports the clinical benefits of exercise, our understanding of the molecular underpinnings of its benefits in the heart remains incomplete. Pinpointing...

Full description

Saved in:
Bibliographic Details
Main Authors: Khetarpal, Sumeet A. (Author) , Li, Haobo (Author) , Lerchenmüller, Carolin (Author) , Rhee, James (Author) , Rosenzweig, Anthony (Author)
Format: Article (Journal)
Language:English
Published: 7 July 2025
In: Circulation research
Year: 2025, Volume: 137, Issue: 2, Pages: 163-183
ISSN:1524-4571
DOI:10.1161/CIRCRESAHA.125.325762
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1161/CIRCRESAHA.125.325762
Verlag, kostenfrei, Volltext: https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.125.325762
Get full text
Author Notes:Sumeet A. Khetarpal, Haobo Li, Carolin Lerchenmüller, James Rhee, Anthony Rosenzweig
Description
Summary:Exercise exerts myriad cardiovascular benefits and protects against most forms of cardiovascular disease. While extensive epidemiological evidence supports the clinical benefits of exercise, our understanding of the molecular underpinnings of its benefits in the heart remains incomplete. Pinpointing these mechanisms is essential to identifying molecular targets modulated by exercise for therapeutic gain. In this review, we discuss the cellular and molecular mechanisms through which exercise benefits the heart, with a focus on the cardiomyocyte. We highlight cardiomyocyte-secreted mediators of intercell communication, intracellular signaling pathways, transcriptional regulation, and posttranscriptional mechanisms through noncoding RNAs that have been implicated in the cardiac exercise response. We emphasize pathways and mediators regulated by exercise training that may provide therapeutic targets in heart failure.
Item Description:Online veröffentlicht: 3. Juli 2025
Gesehen am 05.11.2025
Physical Description:Online Resource
ISSN:1524-4571
DOI:10.1161/CIRCRESAHA.125.325762

Similar Items