Immunohistochemical heterogeneity of nerve cells in the human adrenal gland with special reference to substance P
Neurons in the human adrenal medulla, stained by the NADH-diaphorase reaction, were counted and their neurochemical markers were investigated by double labeling immunofluorescence with special reference to substance P. The findings indicate a significant participation of intramedullary nerve cell bo...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
April 1, 1996
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| In: |
Journal of histochemistry & cytochemistry
Year: 1996, Volume: 44, Issue: 4, Pages: 369-375 |
| ISSN: | 1551-5044 |
| DOI: | 10.1177/44.4.8601696 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1177/44.4.8601696
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| Author Notes: | Mario Colombo-Benkmann, Lars Klimaschewski, and Christina Heym |
| Summary: | Neurons in the human adrenal medulla, stained by the NADH-diaphorase reaction, were counted and their neurochemical markers were investigated by double labeling immunofluorescence with special reference to substance P. The findings indicate a significant participation of intramedullary nerve cell bodies in human adrenal innervation with 40.4 neurons/mm3 adrenal medulla. Substance P-immunoreactive neurons, which made up approximately 20% of all neurons, exhibited heterogeneity by co-localization of immunoreactivities for dynorphin, for cholecystokinin, and for neurofilament triplet. Substance-P-immunolabeled neurons were always nonreactive for calcitonin gene-related peptide, for vasoactive intestinal polypeptide, or for tyrosine hydroxylase, the rate-limiting enzyme of catecholamine synthesis. These chemical phenotypes of intramedullary neurons reveal immunohistochemical similarities with postganglionic neurons in parasympathetic ganglia or with enteric neurons, suggesting a hitherto unrecognized functional significance of the intrinsic nervous system in the human adrenal gland. |
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| Item Description: | Gesehen am 06.11.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1551-5044 |
| DOI: | 10.1177/44.4.8601696 |