Immunohistochemical localization of calcitonin gene-related peptide and cotransmitters in a subpopulation of post-ganglionic neurons in the porcine inferior mesenteric ganglion
Applying double-fluorescence immunohistochemistry, adrenergic and non-adrenergic postganglionic sympathetic neurons, in the porcine inferior mesenteric ganglion (IMG) are subdivided according to size and cotransmitter content. Calcitonin gene related peptide (CGRP)-immunoreactive (IR) neurons are de...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
June 1992
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| In: |
Acta histochemica
Year: 1992, Volume: 92, Issue: 2, Pages: 138-146 |
| ISSN: | 1618-0372 |
| DOI: | 10.1016/S0065-1281(11)80075-9 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0065-1281(11)80075-9 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0065128111800759 
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| Author Notes: | Mariusz Majewski, Christine Heym |
| Summary: | Applying double-fluorescence immunohistochemistry, adrenergic and non-adrenergic postganglionic sympathetic neurons, in the porcine inferior mesenteric ganglion (IMG) are subdivided according to size and cotransmitter content. Calcitonin gene related peptide (CGRP)-immunoreactive (IR) neurons are demonstrated to belong to the non-adrenergic, i.e. tyrosine hydroxylase- and DOPAmine-ß-hydroxylase-(DßH)-negative subpopulation of postganglionic perikarya. Virtually all of the CGRP-IR postganglionic neurons exhibit colocalization with somatostatin (SOM), and, some of them with neuropeptide tyrosine (NPY). Additionally, NPY-, SOM-, and NPY/SOM-IR subpopulations of adrenergic and non-adrenergic neurons are observed. CGRP-immunoreactivity is seen in dense networks of intraganglionic varicose nerve fibres, adjacent to the TH-and SOM-IR neurons. NPY-IR perikarya are sparsely supplied by CGRP-IR fibres. SOM- and NPY-IR nerve fibres also exist in the inferior mesenteric ganglion. The functional relevance of CGRP-IR postganglionic neurons, as well as target organs of these neurons remain to be elucidated. |
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| Item Description: | Elektronische Reproduktion der Druck-Ausgabe 20. Februar 2012 Gesehen am 06.11.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1618-0372 |
| DOI: | 10.1016/S0065-1281(11)80075-9 |