Childhood maltreatment and adult diseases in the general population: the mediating role of smoking and overweight in a time-sequence design

Childhood maltreatment is associated with an unhealthier lifestyle in adulthood and an increased risk of mental and somatic health problems, although the underlying pathways remain unclear. This study examined whether smoking and overweight mediate the association between childhood abuse/neglect and...

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Main Authors: Klinger-König, Johanna (Author) , Streit, Fabian (Author) , Völker, Maja (Author) , Frank, Josef (Author) , Sekula, Peggy (Author) , Jaskulski, Stefanie (Author) , Leitzmann, Michael (Author) , Meinke-Franze, Claudia (Author) , Schmidt, Carsten O. (Author) , Keil, Thomas (Author) , Willich, Stefan N. (Author) , Pischon, Tobias (Author) , Velásquez, Ilais M. (Author) , Frost, Jonas (Author) , Schmidt, Börge (Author) , Heise, Jana-Kristin (Author) , Klett-Tammen, Carolina J. (Author) , Koch, Lena (Author) , Obi, Nadia (Author) , Harth, Volker (Author) , Mons, Ute (Author) , Berger, Klaus (Author) , Greiser, Karin Halina (Author) , Mikolajczyk, Rafael (Author) , Schulze, Matthias Bernd (Author) , Grabe, Hans Jörgen (Author)
Format: Article (Journal)
Language:English
Published: 27 October 2025
In: BMC public health
Year: 2025, Volume: 25, Pages: 1-17
ISSN:1471-2458
DOI:10.1186/s12889-025-24854-y
Online Access:Resolving-System, kostenfrei: https://doi.org/10.1186/s12889-025-24854-y
Resolving-System, kostenfrei: https://doi.org/10.25673/121109
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Author Notes:Johanna Klinger-König, Fabian Streit, Maja P. Völker, Josef Frank, Peggy Sekula, Stefanie Jaskulski, Michael Leitzmann, Claudia Meinke-Franze, Carsten O. Schmidt, Thomas Keil, Stefan N. Willich, Tobias Pischon, Ilais M. Velásquez, Jonas Frost, Börge Schmidt, Jana-Kristin Heise, Carolina J. Klett-Tammen, Lena Koch-Gallenkamp, Nadia Obi, Volker Harth, Ute Mons, Klaus Berger, Karin H. Greiser, Rafael Mikolajczyk, Matthias B. Schulze, Hans J. Grabe
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Summary:Childhood maltreatment is associated with an unhealthier lifestyle in adulthood and an increased risk of mental and somatic health problems, although the underlying pathways remain unclear. This study examined whether smoking and overweight mediate the association between childhood abuse/neglect and frequent adult diseases, including cancer, myocardial infarction, stroke, type 2 diabetes, chronic obstructive pulmonary disease, depression, and anxiety.
Item Description:Gesehen am 10.12.2025
Physical Description:Online Resource
ISSN:1471-2458
DOI:10.1186/s12889-025-24854-y