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Complementary role of transcriptomic endotyping and protein-based biomarkers for risk stratification in sepsis-associated acute kidney injury

Sepsis-associated acute kidney injury (SA-AKI) is a prevalent and severe complication in critically ill patients. However, diagnostic and therapeutic advancements have been hindered by the biological heterogeneity underlying the disease. Both transcriptomic endotyping and biomarker profiling have be...

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Main Authors: Tavris, Bengi S. (Author) , Morath, Christian (Author) , Rupp, Christoph (Author) , Szudarek, Roman (Author) , Uhle, Florian (Author) , Sweeney, Timothy E. (Author) , Liesenfeld, Oliver (Author) , Fiedler-Kalenka, Mascha (Author) , Dubler, Simon (Author) , Zeier, Martin (Author) , Schmitt, Felix (Author) , Weigand, Markus A. (Author) , Brenner, Thorsten (Author) , Nußhag, Christian (Author)
Format: Article (Journal)
Language:English
Published: 26 March 2025
In: Critical care
Year: 2025, Volume: 29, Pages: 1-13
ISSN:1466-609X
DOI:10.1186/s13054-025-05361-3
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13054-025-05361-3
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Author Notes:Bengi S. Tavris, Christian Morath, Christoph Rupp, Roman Szudarek, Florian Uhle, Timothy E. Sweeney, Oliver Liesenfeld, Mascha O. Fiedler-Kalenka, Simon Dubler, Martin Zeier, Felix C. F. Schmitt, Markus A. Weigand, Thorsten Brenner and Christian Nusshag
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Summary:Sepsis-associated acute kidney injury (SA-AKI) is a prevalent and severe complication in critically ill patients. However, diagnostic and therapeutic advancements have been hindered by the biological heterogeneity underlying the disease. Both transcriptomic endotyping and biomarker profiling have been proposed individually to identify molecular subtypes of sepsis and may enhance risk stratification. This study aimed to evaluate the utility of combining transcriptomic endotyping with protein-based biomarkers for improving risk stratification in SA-AKI.
Item Description:Gesehen am 10.11.2025
Physical Description:Online Resource
ISSN:1466-609X
DOI:10.1186/s13054-025-05361-3

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