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Nitric oxide synthase in cardiac nerve fibers and neurons of rat and guinea pig heart.

Participation of nitric oxide (NO) in the autonomic innervation of rat and guinea pig hearts was investigated by applying the NADPH diaphorase technique and immunohistochemistry with NO synthase antiserum. We present evidence that NO synthase is localized in cardiac ganglion cells and nerve fibers i...

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Main Authors: Klimaschewski, Lars Peter (Author) , Kummer, Wolfgang (Author) , Mayer, Bernd (Author) , Couraud, Jean Yves (Author) , Preissler, Ulrike (Author) , Philippin, Bärbel (Author) , Heym, Christine (Author)
Format: Article (Journal)
Language:English
Published: December 1, 1992
In: Circulation research
Year: 1992, Volume: 71, Issue: 6, Pages: 1533-1537
ISSN:1524-4571
DOI:10.1161/01.RES.71.6.1533
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1161/01.RES.71.6.1533
Verlag, lizenzpflichtig, Volltext: https://www.ahajournals.org/doi/10.1161/01.RES.71.6.1533
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Author Notes:Lars Klimaschewski, Wolfgang Kummer, Bernd Mayer, Jean Yves Couraud, Ulrike Preissler, Bärbel Philippin, and Christine Heym
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Summary:Participation of nitric oxide (NO) in the autonomic innervation of rat and guinea pig hearts was investigated by applying the NADPH diaphorase technique and immunohistochemistry with NO synthase antiserum. We present evidence that NO synthase is localized in cardiac ganglion cells and nerve fibers innervating the sinuatrial and atrioventricular nodes, the myocardium, local neurons, coronary arteries, and pulmonary vessels, suggesting an involvement of NO in neurogenic heart rate regulation, myocardial cell function, neuronal transmission in cardiac ganglia, and coronary as well as pulmonary vasodilation.
Item Description:Gesehen am 10.11.2025
Physical Description:Online Resource
ISSN:1524-4571
DOI:10.1161/01.RES.71.6.1533

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