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Bradykinin excretion is increased in severely hyperglycemic streptozotocin-diabetic rats

The renal kallikrein-kinin system (KKS) was studied in pair-fed streptozotocin (STZ)-induced diabetic rats and compared with age-matched controls. Twelve weeks after STZ injection, rats were normotensive, showed hyperglycemia, proteinuria, polydipsia and reduced glomerular filtration rate (GFR) and...

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Main Authors: Tschöpe, Carsten (Author) , Gavriluk, Vitali (Author) , Reinecke, Alexander (Author) , Seidl, Ulrich (Author) , Riester, Udo (Author) , Hilgenfeldt, Ulrich (Author) , Ritz, Eberhard (Author) , Unger, Thomas (Author)
Format: Article (Journal)
Language:English
Published: June 1996
In: Immunopharmacology
Year: 1996, Volume: 33, Issue: 1, Pages: 344-348
ISSN:1879-047X
DOI:10.1016/0162-3109(96)00094-X
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/0162-3109(96)00094-X
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/016231099600094X
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Author Notes:Carsten Tschöpe, Vitali Gavriluk, Alexander Reinecke, Ulrich Seidl, Udo Riester, Ulrich Hilgenfeldt, Eberhard Ritz, Thomas Unger
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Summary:The renal kallikrein-kinin system (KKS) was studied in pair-fed streptozotocin (STZ)-induced diabetic rats and compared with age-matched controls. Twelve weeks after STZ injection, rats were normotensive, showed hyperglycemia, proteinuria, polydipsia and reduced glomerular filtration rate (GFR) and body weight. The activities of urinary prekallikrein (PKLK) and kallikrein (KLK) were reduced accompanied by an up to 3-fold increase of bradykinin (BK) excretion compared to controls. The increased BK excretion suggests that the renal KKS in STZ-diabetes is activated and that the reduction in urinary PKLK and KLK activity may be due to an increased consumption of these enzymes or to a negative feedback mechanism. The stimulation of the renal KKS in STZ-diabetes could reflect an attempt of the organism to balance glomerular hypertension.
Item Description:Elektronische Reproduktion der Druck-Ausgabe 12. März 1999
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Physical Description:Online Resource
ISSN:1879-047X
DOI:10.1016/0162-3109(96)00094-X

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