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Combined spatial and dosimetric recurrence pattern analysis in head and neck squamous cell carcinoma following postoperative (chemo)radiotherapy

Advancements in nodal staging for head and neck squamous cell carcinoma (HNSCC) have prompted radiotherapy de-escalation trials to reduce irradiation of electively treated neck regions, with the goal of improving treatment tolerability. While volumetric de-escalation has shown promise in definitive...

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Main Authors: Schröter, Philipp (Author) , Lau, Hoi Hin (Author) , Stritzke, Florian (Author) , Franke, Henrik (Author) , Kozyra, Katharina (Author) , Regnery, Sebastian (Author) , Bauer, Lukas (Author) , Deng, Maximilian (Author) , Dvornikovich, Katharina (Author) , Hofmann, Anna (Author) , Wessels, Lars (Author) , Semmelmayer, Karl (Author) , Moratin, Julius (Author) , Ristow, Oliver (Author) , Hoffmann, Jürgen (Author) , Plinkert, Peter K. (Author) , Dyckhoff, Gerhard (Author) , Debus, Jürgen (Author) , Held, Thomas (Author)
Format: Article (Journal)
Language:English
Published: 23 April 2025
In: Radiation oncology
Year: 2025, Volume: 20, Pages: 1-12
ISSN:1748-717X
DOI:10.1186/s13014-025-02641-8
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13014-025-02641-8
Verlag, kostenfrei, Volltext: https://ro-journal.biomedcentral.com/
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Author Notes:Philipp Schröter, Hoi Hin Lau, Florian Stritzke, Henrik Franke, Katharina Weusthof, Sebastian Regnery, Lukas Bauer, Maximilian Deng, Katharina Dvornikovich, Anna Hofmann, Lars Wessel, Karl Semmelmayer, Julius Moratin, Oliver Ristow, Jürgen Hoffmann, Peter Plinkert, Gerhard Dyckhoff, Jürgen Debus and Thomas Held
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Summary:Advancements in nodal staging for head and neck squamous cell carcinoma (HNSCC) have prompted radiotherapy de-escalation trials to reduce irradiation of electively treated neck regions, with the goal of improving treatment tolerability. While volumetric de-escalation has shown promise in definitive radiotherapy of HNSCC, limited data exist regarding its safety in the postoperative treatment setting. This study aimed to assess dose-level-specific locoregional recurrence patterns following standard postoperative (chemo)radiotherapy in a mixed HNSCC cohort to inform risk-adaptive radiotherapy strategies.
Item Description:Gesehen am 12.11.2025
Physical Description:Online Resource
ISSN:1748-717X
DOI:10.1186/s13014-025-02641-8

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