The impact of brain-derived neurotrophic factor gene polymorphisms on post-stroke naming in aphasia
Post-stroke aphasia, or language deficits after stroke, afflicts 20-30% of survivors and often persists into the chronic phase. The protein brain-derived neurotrophic factor has been identified as important for neuroplasticity, and is regulated by the brain-derived neurotrophic factor gene. A patien...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
July 14, 2025
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| In: |
PLOS ONE
Year: 2025, Volume: 20, Issue: 7, Pages: 1-12 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0327320 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1371/journal.pone.0327320 Verlag, kostenfrei, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0327320 
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| Author Notes: | Matilda Randighieri, Alyssa Devine, Lindsey Kelly, Victoria Tilton-Bolowsky, Voss Neal, Joseph Kang, Julian Bösel, Argye Elizabeth Hillis, Melissa D. Stockbridge |
| Summary: | Post-stroke aphasia, or language deficits after stroke, afflicts 20-30% of survivors and often persists into the chronic phase. The protein brain-derived neurotrophic factor has been identified as important for neuroplasticity, and is regulated by the brain-derived neurotrophic factor gene. A patient’s brain-derived neurotrophic factor genotype may influence their post-stroke aphasia recovery. This study aimed to investigate the impact of a single nucleotide polymorphism in the brain-derived neurotrophic factor gene, rs6265, on language recovery. We hypothesized that individuals with the most common polymorphism would exhibit better chronic naming performance and a more favorable recovery trajectory from poor acute performance to strong chronic outcomes compared to those without the polymorphism. We retrospectively analyzed data from 77 participants with post-stroke aphasia from three recent or ongoing studies that included both repeated standardized picture naming assessments in the acute, subacute, and chronic phases and brain-derived neurotrophic factor genotyping. Statistical analyses controlled for acute performance and lesion volume when evaluating the effect of brain-derived neurotrophic factor genotype on the probability of better chronic language recovery (Aim 1) and on the probability of a person with poor acute performance later having strong performance in the subacute to chronic period (Aim 2). Results indicated that those with the most common polymorphism had a 33% higher likelihood of high naming scores in the chronic phase compared to those with the with less common polymorphisms (with a methionine allele). Individuals with the typical polymorphism whose acute naming was below average after stroke exhibited a 24% higher likelihood of recovering to be above average. Brain-derived neurotrophic factor status was not a significant independent predictor of outcome in either model. Our results suggest that the effect of brain-derived neurotrophic factor polymorphisms on chronic post-stroke aphasia recovery is, at best, modest and underscores the importance of individualized approaches to neurorehabilitation. |
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| Item Description: | Gesehen am 13.11.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0327320 |