Buchumschlag

Left ventricular ejection fraction predicts outcomes in different subgroups of patients undergoing coronary angiography

Objectives: To evaluate the long-term prognostic value of left ventricular ejection fraction (LVEF) in consecutive patients undergoing invasive coronary angiography (CA). Background: LVEF is a key prognostic marker in cardiovascular disease, but its value across different clinical indications for CA...

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Hauptverfasser: Steffen, Henning Johann (VerfasserIn) , Schupp, Tobias (VerfasserIn) , Abumayyaleh, Mohammad S. A. (VerfasserIn) , Kuhn, Lasse (VerfasserIn) , Steinke, Philipp (VerfasserIn) , Dudda, Jonas (VerfasserIn) , Weidner, Kathrin (VerfasserIn) , Rusnak, Jonas (VerfasserIn) , Jannesari, Mahboubeh (VerfasserIn) , Siegel, Fabian (VerfasserIn) , Dürschmied, Daniel (VerfasserIn) , Behnes, Michael (VerfasserIn) , Akın, Ibrahim (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 23 July 2025
In: Journal of Clinical Medicine
Year: 2025, Jahrgang: 14, Heft: 15, Pages: 1-14
ISSN:2077-0383
DOI:10.3390/jcm14155219
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/jcm14155219
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2077-0383/14/15/5219
Volltext
Verfasserangaben:Henning Johann Steffen, Tobias Schupp, Mohammad Abumayyaleh, Lasse Kuhn, Philipp Steinke, Jonas Dudda, Kathrin Weidner, Jonas Rusnak, Mahboubeh Jannesari, Fabian Siegel, Daniel Duerschmied, Michael Behnes and Ibrahim Akin
Beschreibung
Zusammenfassung:Objectives: To evaluate the long-term prognostic value of left ventricular ejection fraction (LVEF) in consecutive patients undergoing invasive coronary angiography (CA). Background: LVEF is a key prognostic marker in cardiovascular disease, but its value across different clinical indications for CA remains insufficiently characterized. Methods: Consecutive patients undergoing CA between January 2016 and August 2022 were retrospectively included at one institution. Patients were stratified into four LVEF groups: ≥ 55%, 45-54%, 35-44%, and <35%. The primary endpoint was rehospitalization for heart failure (HF) at 36 months. Secondary endpoints were acute myocardial infarction (AMI) and coronary revascularization. Kaplan-Meier and multivariable Cox regression analyses were conducted within the entire study cohort and pre-defined subgroups. Results: A total of 6888 patients were included (median age: 71 years; 65.2% males). LVEF < 35% was associated with a higher comorbidity burden and more extensive coronary artery disease (e.g., three-vessel CAD: 38.6% vs. 20.7%, p < 0.001). Event rates for HF rehospitalization and AMI increased progressively with declining LVEF, while revascularization rates varied across categories. Statistically significant differences across LVEF groups were observed for all three endpoints in unadjusted analyses (log-rank p < 0.001). In multivariable models, LVEF < 35% independently predicted HF rehospitalization (HR = 3.731, p < 0.001) and AMI (HR = 4.184, p < 0.001), but not revascularization (HR = 0.867, p = 0.378). The prognostic association was demonstrated across all subgroups stratified by age, sex, subtype of acute coronary syndrome, and CAD severity. Conclusions: Reduced LVEF is an independent predictor of HF rehospitalization and AMI in patients undergoing coronary angiography, irrespective of its indication, whereas no independent association was observed with coronary revascularization.
Beschreibung:Gesehen am 13.11.2025
Beschreibung:Online Resource
ISSN:2077-0383
DOI:10.3390/jcm14155219

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