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Office blood pressure and obesity in children with X-linked hypophosphatemia

X-linked hypophosphatemia (XLH) is the most common inherited form of hypophosphatemic rickets. Children with XLH have an increased risk of obesity, which may promote high blood pressure, but data on blood pressure in XLH are inconclusive. We aimed to assess blood pressure and its determinants in ped...

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Main Authors: Böckmann, Ineke (Author) , Leifheit-Nestler, Maren (Author) , Rehberg, Mirko (Author) , Spartà, Giuseppina (Author) , Evers, Katrina (Author) , Schlingmann, Karl Peter (Author) , Kemper, Markus J. (Author) , Richter-Unruh, Annette (Author) , Hiort, Olaf (Author) , Grohmann-Held, Karina (Author) , Derichs, Ute (Author) , Freiberg, Clemens (Author) , Weitz, Marcus (Author) , Dunstheimer, Desiree (Author) , Schmid, Elmar (Author) , John-Kroegel, Ulrike (Author) , Metzing, Oliver (Author) , Heger, Sabine (Author) , Jorch, Norbert (Author) , Staude, Hagen (Author) , Patzer, Ludwig (Author) , Wühl, Elke (Author) , Zivicnjak, Miroslav (Author) , Schnabel, Dirk (Author) , Haffner, Dieter (Author)
Format: Article (Journal)
Language:English
Published: 2025
In: Calcified tissue international
Year: 2025, Volume: 116, Pages: 1-11
ISSN:1432-0827
DOI:10.1007/s00223-025-01363-z
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00223-025-01363-z
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Author Notes:Ineke Böckmann, Maren Leifheit-Nestler, Mirko Rehberg, Giuseppina Spartà, Katrina Evers, Karl Peter Schlingmann, Markus J. Kemper, Annette Richter-Unruh, Olaf Hiort, Karina Grohmann-Held, Ute Derichs, Clemens Freiberg, Marcus Weitz, Desiree Dunstheimer, Elmar Schmid, Ulrike John-Kroegel, Oliver Metzing, Sabine Heger, Norbert Jorch, Hagen Staude, Ludwig Patzer, Elke Wühl, Miroslav Zivicnjak, Dirk Schnabel, Dieter Haffner, on behalf of the German Society for Pediatric Nephrology (GPN) and the German Society for Pediatric and Adolescent Endocrinology and Diabetology (DGPAED)
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Summary:X-linked hypophosphatemia (XLH) is the most common inherited form of hypophosphatemic rickets. Children with XLH have an increased risk of obesity, which may promote high blood pressure, but data on blood pressure in XLH are inconclusive. We aimed to assess blood pressure and its determinants in pediatric XLH patients. We conduct a prospective, multicenter observational study of children with XLH in Germany and Switzerland. Office blood pressure and body mass index (BMI) were annually measured in 128 pediatric XLH patients with a median follow-up of 2 years (range 1-6). Potential predictors of blood pressure were investigated by Spearman correlation. Seventeen percent of patients were treated with phosphate supplements and active vitamin D for a median of 8 years, 83% of patients received burosumab for 2.3 years with 3.1 years of prior treatment with phosphate supplements and active vitamin D. Median systolic (0.75 z-score) and diastolic (0.32 z-score) blood pressure and BMI (0.72 z-score) were increased compared to healthy children (each p < 0.01). The prevalence of obesity (9.8% vs. 3%), arterial hypertension (26.2% vs. 5%), and high-normal blood pressure (22.9% vs. 5%) was higher in the XLH cohort compared to the general pediatric population (each p < 0.001). Spearman rank correlation analysis revealed significant associations between both systolic (r = 0.24; p < 0.01) and diastolic (r = 0.20; p < 0.05) blood pressure with BMI, while the mode of treatment, i.e. burosumab versus phosphate supplements and active vitamin D, was no significant correlate. Children with XLH present with elevated office blood pressure values, associated with elevated BMI.
Item Description:Online veröffentlicht: 28. März 2025
Gesehen am 14.11.2025
Physical Description:Online Resource
ISSN:1432-0827
DOI:10.1007/s00223-025-01363-z

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