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Clonal hematopoiesis-associated motoric deficits caused by monocyte-derived microglia accumulating in aging mice

Microglia are parenchymal brain macrophages that are established during embryogenesis and form a self-containing cellular compartment that resists seeding with cells derived from adult definitive hematopoiesis. We report that monocyte-derived macrophages (MoMΦs) accumulate in the brain of aging mice...

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Main Authors: Kim, Jung-Seok (Author) , Trzebanski, Sébastien (Author) , Shin, Sun-Hye (Author) , Schori, Lior (Author) , Frumer Friedman, Gal Ronit (Author) , Ilani, Noa Chapal (Author) , Kadam, Aditee (Author) , Vicario, Rocio (Author) , Aust, Oliver (Author) , Bugaeva, Polina (Author) , Piatek, Sylwia (Author) , Ismajli, Laura Kate (Author) , Hoffmann, Christian Johannes (Author) , Scheller, Marina (Author) , Boura-Halfon, Sigalit (Author) , Kaushansky, Nathali (Author) , Golani, Ofra (Author) , Solomon, Aryeh (Author) , Liu, Zhaoyuan (Author) , Amann, Lukas (Author) , Böhm-Sturm, Philipp (Author) , Koch, Stefan Paul (Author) , Wenger, Nikolaus (Author) , Ginhoux, Florent (Author) , Prinz, Marco (Author) , Avraham, Roi (Author) , Harms, Christoph (Author) , Geissmann, Frederic (Author) , Müller-Tidow, Carsten (Author) , Uderhardt, Stefan (Author) , Milenkovic, Ivan (Author) , Shlush, Liran (Author) , Jung, Steffen (Author)
Format: Article (Journal)
Language:English
Published: 27 May 2025
In: Cell reports
Year: 2025, Volume: 44, Issue: 5, Pages: 1-22
ISSN:2211-1247
DOI:10.1016/j.celrep.2025.115609
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.celrep.2025.115609
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S2211124725003808
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Author Notes:Jung-Seok Kim, Sébastien Trzebanski, Sun-Hye Shin, Lior Schori, Gal Ronit Frumer Friedman, Noa Chapal Ilani, Aditee Kadam, Rocio Vicario, Oliver Aust, Polina Bugaeva, Sylwia Piatek, Laura Kate Ismajli, Christian Johannes Hoffmann, Marina Scheller, Sigalit Boura-Halfon, Nathali Kaushansky, Ofra Golani, Aryeh Solomon, Zhaoyuan Liu, Lukas Amann, Philipp Böhm-Sturm, Stefan Paul Koch, Nikolaus Wenger, Florent Ginhoux, Marco Prinz, Roi Avraham, Christoph Harms, Frederic Geissmann, Carsten Müller-Tidow, Stefan Uderhardt, Ivan Milenkovic, Liran Shlush, and Steffen Jung
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Summary:Microglia are parenchymal brain macrophages that are established during embryogenesis and form a self-containing cellular compartment that resists seeding with cells derived from adult definitive hematopoiesis. We report that monocyte-derived macrophages (MoMΦs) accumulate in the brain of aging mice with distinct topologies, including the nigrostriatum and medulla but not the frontal cortex. Parenchymal MoMΦs adopt bona fide microglia morphology and expression profiles. Due to their hematopoietic stem cell (HSC) derivation, monocyte-derived microglia (MoMg) are unlike yolk-sac-derived cells, targets of clonal hematopoiesis (CH). Indeed, using a chimeric transfer model, we show that the hematopoietic expression of DNMT3AR882H, a prominent human CH variant, renders MoMg pathogenic and promotes motor deficits resembling atypical Parkinsonian disorders. Collectively, we establish that MoMg progressively seed the brain of healthy aging mice, accumulate in selected areas, and, when carrying a somatic mutation associated with CH, can cause brain pathology.
Item Description:Gesehen am 14.11.2025
Physical Description:Online Resource
ISSN:2211-1247
DOI:10.1016/j.celrep.2025.115609

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