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PERIoperative antibiotic prophylaxis in PANCreatic surgery (PeriPANC): protocol for a prospective observational study comparing antibiotic regimens and their impact on postoperative outcomes in pancreatic surgery

Introduction Despite advancements in pancreatic surgery, postoperative infections—particularly surgical site infections (SSIs), which occur in 6-17% of cases—continue to be a leading cause of morbidity. Effective perioperative antibiotic prophylaxis is essential, though the optimal regimen remains u...

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Hauptverfasser: Weber, Sophie (Verfasst von) , Siegel, Niels (Verfasst von) , Hank, Thomas (Verfasst von) , Halm, Darius (Verfasst von) , Kinny-Köster, Benedict (Verfasst von) , Heckler, Max (Verfasst von) , Harnoß, Jonathan M. (Verfasst von) , Saeedi, Mohammed al (Verfasst von) , Probst, Pascal (Verfasst von) , Michalski, Christoph (Verfasst von) , Loos, Martin (Verfasst von) , Harnoß, Julian-Camill (Verfasst von)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: August 1, 2025
In: BMJ open
Year: 2025, Jahrgang: 15, Heft: 7, Pages: 1-6
ISSN:2044-6055
DOI:10.1136/bmjopen-2025-103572
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1136/bmjopen-2025-103572
Verlag, kostenfrei, Volltext: https://bmjopen.bmj.com/content/15/7/e103572
Volltext
Verfasserangaben:Sophie Weber, Niels Siegel, Thomas Hank, Darius Halm, Benedict Kinny-Köster, Max Heckler, Jonathan M. Harnoss, Mohammed Al-Saeedi, Pascal Probst, Christoph W. Michalski, Martin Loos, Julian C. Harnoss
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Zusammenfassung:Introduction Despite advancements in pancreatic surgery, postoperative infections—particularly surgical site infections (SSIs), which occur in 6-17% of cases—continue to be a leading cause of morbidity. Effective perioperative antibiotic prophylaxis is essential, though the optimal regimen remains unclear. Recent studies indicate that broad-spectrum antibiotics may be more effective than cephalosporins; however, agents like piperacillin/tazobactam, despite broader coverage, pose risks of resistance development and increased costs. - Methods and analysis The PERIoperative antibiotic prophylaxis in PANCreatic surgery (PeriPANC) study is a single-centre, prospective, observational study investigating the effectiveness of piperacillin/tazobactam for perioperative antibiotic prophylaxis in pancreatic surgery, compared with a retrospective cohort previously treated with ampicillin/sulbactam. Around 300 adult patients undergoing pancreatic resection will be included. The primary outcome is the incidence of SSI; secondary outcomes include other infectious complications, microbial resistance and healthcare utilisation. Differences between groups will be analysed with analysis of covariance. - Ethics and dissemination The PeriPANC study has been reviewed and approved by the local ethics committee of Heidelberg University Hospital (S-087/2025). As all patients receive standard care and no additional data are collected beyond routine documentation, informed consent is not required. Findings will be disseminated through peer-reviewed publications. The results are expected to inform clinical practice and guideline development in the field of perioperative infection prevention in pancreatic surgery. - Trial registration number German Clinical Trials Register (DRKS): DRKS00036546.
Beschreibung:Gesehen am 25.11.2025
Beschreibung:Online Resource
ISSN:2044-6055
DOI:10.1136/bmjopen-2025-103572

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