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Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions

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Glioblastoma is the most common type of malignant primary brain tumor and a major cause of morbidity and mortality. In 2021, the World Health Organization updated the classification of Central Nervous System (CNS) tumors to restrict glioblastomas to isocitrate dehydrogenase-wildtype (IDHwt) tumors,...

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Main Authors: Wen, Patrick Y. (Author) , Weller, Michael (Author) , Lee, Eudocia Q (Author) , Touat, Mehdi (Author) , Khasraw, Mustafa (Author) , Rahman, Rifaquat (Author) , Platten, Michael (Author) , Lim, Michael (Author) , Winkler, Frank (Author) , Horbinski, Craig (Author) , Verhaak, Roel G W (Author) , Huang, Raymond Y (Author) , Ahluwalia, Manmeet S (Author) , Albert, Nathalie L (Author) , Tonn, Joerg-Christian (Author) , Schiff, David (Author) , Barnholtz-Sloan, Jill S (Author) , Ostrom, Quinn (Author) , Aldape, Kenneth D (Author) , Batchelor, Tracy T (Author) , Bindra, Ranjit S (Author) , Chiocca, E Antonio (Author) , Cloughesy, Timothy F (Author) , DeGroot, John F (Author) , French, Pim (Author) , Galanis, Evanthia (Author) , Galldiks, Norbert (Author) , Gilbert, Mark R (Author) , Hegi, Monika E (Author) , Lassman, Andrew B (Author) , Le Rhun, Emilie (Author) , Mehta, Minesh P (Author) , Mellinghoff, Ingo K (Author) , Minniti, Giuseppe (Author) , Roth, Patrick (Author) , Sanson, Marc (Author) , Taphoorn, Andreas, Martin J B (Author) , Weiss, von Deimling, Tobias (Author) , Wick, Wolfgang (Author) , Zadeh, Gelareh (Author) , Reardon, David A (Author) , Chang, Susan M (Author) , Short, Susan C (Author) , van den Bent, Martin J (Author) , Preusser, Matthias (Author)
Format: Article (Journal)
Language:English
Published: 13 August 2025
In: Neuro-Oncology
Year: 2025, Pages: 1-38
ISSN:1523-5866
DOI:10.1093/neuonc/noaf177
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1093/neuonc/noaf177
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Author Notes:Patrick Y. Wen, Michael Weller, Eudocia Q. Lee, Mehdi Touat, Mustafa Khasraw, Rifaquat Rahman, Michael Platten, Michael Lim, Frank Winkler, Craig Horbinski, Roel G.W. Verhaak, Raymond Y. Huang, Manmeet S. Ahluwalia, Nathalie L. Albert, Joerg-Christian Tonn, David Schiff, Jill S. Barnholtz-Sloan, Quinn Ostrom, Kenneth D. Aldape, Tracy T. Batchelor, Ranjit S. Bindra, E. Antonio Chiocca, Timothy F. Cloughesy, John F. DeGroot, Pim French, Evanthia Galanis, Norbert Galldiks, Mark R. Gilbert, Monika E. Hegi, Andrew B. Lassman, Emilie Le Rhun, Minesh P. Mehta, Ingo K. Mellinghoff, Giuseppe Minniti, Patrick Roth, Marc Sanson, Andreas, Martin J.B. Taphoorn, von Deimling, Tobias Weiss, Wolfgang Wick, Gelareh Zadeh, David A. Reardon, Susan M. Chang, Susan C. Short, Martin J. van den Bent, Matthias Preusser
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Summary:Glioblastoma is the most common type of malignant primary brain tumor and a major cause of morbidity and mortality. In 2021, the World Health Organization updated the classification of Central Nervous System (CNS) tumors to restrict glioblastomas to isocitrate dehydrogenase-wildtype (IDHwt) tumors, improving understanding of the prognosis and optimal therapy for these tumors. This revision also enables more homogeneous populations of patients to be enrolled in clinical trials, facilitating the evaluation of novel therapies. In this updated consensus review from the Society for Neuro-Oncology (SNO) and the European Association of Neuro-Oncology (EANO), the current management of patients with glioblastoma is discussed. In addition, novel therapies such as immunotherapies, viral therapies, targeted molecular therapies, theranostics, and antibody-drug conjugates will be reviewed, as well as the current challenges and future directions for research.
Item Description:Gesehen am 27.11.2025
Physical Description:Online Resource
ISSN:1523-5866
DOI:10.1093/neuonc/noaf177

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