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Mesenchymal stem cells: a therapeutic approach in fertility restoration in premature ovarian insufficiency

Primary ovarian insufficiency (POI) represents the cessation of ovarian function before age 40 due to follicular depletion or dysfunction. Affecting 1% of women, POI causes infertility and systemic health complications. Current treatments focus on symptom management rather than restoring ovarian fun...

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Main Authors: Hassan, Nourhan (Author) , Hussein, Donia Mohamed (Author) , Malak, Fady Ashraf (Author) , Abdelaziz, Mazen Ashraf (Author) , Boushra, Michael Ibrahim (Author) , Shaalan, Walid (Author) , Elzayat, Emad M. (Author)
Format: Article (Journal)
Language:English
Published: October 2025
In: Stem cell reviews and reports
Year: 2025, Volume: 21, Issue: 7, Pages: 2089-2102
ISSN:2629-3277
DOI:10.1007/s12015-025-10944-2
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s12015-025-10944-2
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s12015-025-10944-2
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Author Notes:Nourhan Hassan, Donia Mohamed Hussein, Fady Ashraf Malak, Mazen Ashraf Abdelaziz, Michael Ibrahim Boushra, Walid Shaalan, Emad M. Elzayat
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Summary:Primary ovarian insufficiency (POI) represents the cessation of ovarian function before age 40 due to follicular depletion or dysfunction. Affecting 1% of women, POI causes infertility and systemic health complications. Current treatments focus on symptom management rather than restoring ovarian function. Mesenchymal stem cells (MSCs) offer promising regenerative potential through paracrine activity, immunomodulation, and tissue repair mechanisms. MSCs from various sources have demonstrated the ability to improve ovarian function, increase follicular survival, and restore hormone production in preclinical models. MSC-derived extracellular vesicles are emerging as cell-free alternatives with similar therapeutic effects. This review examines MSC mechanisms in ovarian restoration, evaluates current evidence, and discusses challenges in clinical translation for POI treatment.
Item Description:Online verfügbar: 01. August 2025
Gesehen am 27.11.2025
Physical Description:Online Resource
ISSN:2629-3277
DOI:10.1007/s12015-025-10944-2

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