Serum interleukin-8 (IL-8) is elevated in patients with metastatic melanoma and correlates with tumour load
It was recently demonstrated that IL-8 is produced by melanoma cell lines and acts as an essential autocrine growth factor. We studied the constitutive production of IL-8 by melanoma cell lines and the serum concentrations in patients with metastatic melanoma. All of 10 melanoma cell lines investiga...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
June 1995
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| In: |
Melanoma research
Year: 1995, Volume: 5, Issue: 3, Pages: 179-182 |
| ISSN: | 1473-5636 |
| DOI: | 10.1097/00008390-199506000-00006 |
| Online Access: | Verlag: https://doi.org/10.1097/00008390-199506000-00006 Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/melanomaresearch/abstract/1995/06000/serum_interleukin_8__il_8__is_elevated_in_patients.6.aspx 
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| Author Notes: | C. Scheibenbogen, T. Möhler, J. Haefele, W. Hunstein, U. Keilholz |
| Summary: | It was recently demonstrated that IL-8 is produced by melanoma cell lines and acts as an essential autocrine growth factor. We studied the constitutive production of IL-8 by melanoma cell lines and the serum concentrations in patients with metastatic melanoma. All of 10 melanoma cell lines investigated constitutively produced IL-8 (mean 315 ± 58 pg/10s cells per 24 h. IL-8 was detectable (mean 159 ± 13.1 pg/ml) in the serum of 21 out of 56 patients by an enzyme-linked immunosorbent assay (ELISA; detection limit < 100 pg/ml). There was a significant correlation with tumour load, whereas no correlation with metastatic sites was found. No increased IL-8 levels were seen in healthy controls or patients with metastatic renal cell carcinoma. These results suggest that IL-8 is constitutively produced by melanoma cells in vivo. |
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| Item Description: | Gesehen am 27.11.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1473-5636 |
| DOI: | 10.1097/00008390-199506000-00006 |