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Heart failure hospitalizations and clinical outcomes in patients undergoing tricuspid transcatheter edge-to-edge repair: insights from EuroTR

Aims To assess the prevalence, prognostic significance, and predictors of heart failure hospitalization (HFH) before and after tricuspid transcatheter edge-to-edge repair (T-TEER) in a large real-world cohort of patients with tricuspid regurgitation (TR). Methods and results Data from the European R...

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Main Authors: Tomasoni, Daniela (Author) , Adamo, Marianna (Author) , Hausleiter, Jörg (Author) , Pezzola, Elisa (Author) , Kresoja, Karl-Patrik (Author) , von Stein, Jennifer (Author) , Fortmeier, Vera (Author) , Pauschinger, Christoph (Author) , Rottbauer, Wolfgang (Author) , Kassar, Mohammad (Author) , Goebel, Bjoern (Author) , Denti, Paolo (Author) , Achouh, Paul (Author) , Rassaf, Tienush (Author) , Barreiro-Perez, Manuel (Author) , Boekstegers, Peter (Author) , Rück, Andreas (Author) , Zdanyte, Monika (Author) , Vincent, Flavien (Author) , Schlegel, Philipp (Author) , von Bardeleben, Ralph-Stephan (Author) , Wild, Mirjam G. (Author) , Besler, Christian (Author) , Brunner, Stephanie (Author) , Toggweiler, Stefan (Author) , Grapsa, Julia (Author) , Patterson, Tiffany (Author) , Thiele, Holger (Author) , Kister, Tobias (Author) , Tarantini, Giuseppe (Author) , Masiero, Giulia (Author) , De Carlo, Marco (Author) , Sticchi, Alessandro (Author) , Konstandin, Mathias (Author) , Van Belle, Eric (Author) , Geisler, Tobias (Author) , Estévez-Loureiro, Rodrigo (Author) , Luedike, Peter (Author) , Karam, Nicole (Author) , Maisano, Francesco (Author) , Lauten, Philipp (Author) , Praz, Fabien (Author) , Kessler, Mirjam (Author) , Kalbacher, Daniel (Author) , Rudolph, Volker (Author) , Iliadis, Christos (Author) , Lurz, Philipp (Author) , Stolz, Lukas (Author) , Metra, Marco (Author)
Format: Article (Journal)
Language:English
Published: August 2025
In: European journal of heart failure
Year: 2025, Volume: 27, Issue: 8, Pages: 1559-1569
ISSN:1879-0844
DOI:10.1002/ejhf.3757
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/ejhf.3757
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ejhf.3757
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Author Notes:Daniela Tomasoni, Marianna Adamo, Jörg Hausleiter, Elisa Pezzola, Karl-Patrik Kresoja, Jennifer von Stein, Vera Fortmeier, Christoph Pauschinger, Wolfgang Rottbauer, Mohammad Kassar, Bjoern Goebel, Paolo Denti, Paul Achouh, Tienush Rassaf, Manuel Barreiro-Perez, Peter Boekstegers, Andreas Rück, Monika Zdanyte, Flavien Vincent, Philipp Schlegel, Ralph-Stephan von Bardeleben, Mirjam G. Wild, Christian Besler, Stephanie Brunner, Stefan Toggweiler, Julia Grapsa, Tiffany Patterson, Holger Thiele, Tobias Kister, Giuseppe Tarantini, Giulia Masiero, Marco De Carlo, Alessandro Sticchi, Mathias H. Konstandin, Eric Van Belle, Tobias Geisler, Rodrigo Estévez-Loureiro, Peter Luedike, Nicole Karam, Francesco Maisano, Philipp Lauten, Fabien Praz, Mirjam Kessler, Daniel Kalbacher, Volker Rudolph, Christos Iliadis, Philipp Lurz, Lukas Stolz, and Marco Metra, the EuroTR Investigators
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Summary:Aims To assess the prevalence, prognostic significance, and predictors of heart failure hospitalization (HFH) before and after tricuspid transcatheter edge-to-edge repair (T-TEER) in a large real-world cohort of patients with tricuspid regurgitation (TR). Methods and results Data from the European Registry of Transcatheter Repair for Tricuspid Regurgitation (EuroTR registry) were analysed. Among 1000 patients undergoing T-TEER for symptomatic TR, 361 (36.1%) had no HFH, 459 (45.9%) had one single HFH, and 180 (18.0%) had multiple HFH the year before T-TEER. Patients with any HFH had more severe heart failure compared with those without. Procedural success (residual TR ≤2) did not differ between patients with single, multiple, or no HFHs before T-TEER. Multivariable analysis showed that a history of HFH was associated with an increased mortality risk (adjusted hazard ratio [HR] 1.51, 95% confidence interval [CI] 1.11-2.06 for single vs. no HFH; adjusted HR 1.63, 95% CI 1.15-2.31 for multiple vs. no HFH), and a higher risk of the combined endpoint of all-cause mortality or HFH. HFH risk decreased by 72% in the 1 year following T-TEER compared to the previous year. Procedural success was the sole independent predictor for reducing HFHs. Conclusions In the EuroTR cohort, a history of HFH was highly prevalent and associated with worse clinical outcomes. Among high-risk patients with symptomatic TR, T-TEER significantly lowered HFH risk, with residual TR grade ≤2 being the key predictor for reduced HFH incidence.
Item Description:Zuerst veröffentlicht: 18. Juli 2025
Gesehen am 28.11.2025
Physical Description:Online Resource
ISSN:1879-0844
DOI:10.1002/ejhf.3757

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