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Autonomous bioluminescence emission from transgenic mice

The bacterial bioluminescence system can be applied to produce autonomous bioluminescence in mammalian cells. Until now, the system has only been stably inserted into cells cultured in vitro. Here, we report the generation of an autobioluminescent transgenic mouse line constitutively expressing the...

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Bibliographic Details
Main Authors: Kiszka, Kamila Anna (Author) , Dullin, Christian (Author) , Steffens, Heinz (Author) , Koenen, Tanja (Author) , Rothermel, Ellen (Author) , Alves, Frauke (Author) , Gregor, Carola (Author)
Format: Article (Journal)
Language:English
Published: 9 Jul 2025
In: Science advances
Year: 2025, Volume: 11, Issue: 28, Pages: 1-5
ISSN:2375-2548
DOI:10.1126/sciadv.ads0463
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1126/sciadv.ads0463
Verlag, kostenfrei, Volltext: https://www.science.org/doi/10.1126/sciadv.ads0463
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Author Notes:Kamila A. Kiszka, Christian Dullin, Heinz Steffens, Tanja Koenen, Ellen Rothermel, Frauke Alves, Carola Gregor
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Summary:The bacterial bioluminescence system can be applied to produce autonomous bioluminescence in mammalian cells. Until now, the system has only been stably inserted into cells cultured in vitro. Here, we report the generation of an autobioluminescent transgenic mouse line constitutively expressing the genes of the bacterial bioluminescence system, enabling substrate-free in vivo luminescence imaging of a living mammal.
Item Description:Gesehen am 01.12.2025
Physical Description:Online Resource
ISSN:2375-2548
DOI:10.1126/sciadv.ads0463

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