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Association between body mass index and the composition of leucocyte-poor platelet-rich plasma: implications for personalized approaches in musculoskeletal medicine

Platelet-rich plasma (PRP) has gained attention in regenerative medicine due to its bio-active proteins with tissue-healing potential. However, heterogeneity in PRP composition remains a major challenge for reproducibility and standardization. Given that body mass index (BMI) affects systemic blood...

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Main Authors: Platzer, Hadrian (Author) , Bork, Alena (Author) , Wellbrock, Malte (Author) , Pourbozorg, Ghazal (Author) , Gantz, Simone (Author) , Sorbi, Reza (Author) , Mayakrishnan, Ravikumar (Author) , Hagmann, Sébastien (Author) , Bangert, Yannic (Author) , Moradi, Babak (Author)
Format: Article (Journal)
Language:English
Published: 8 October 2025
In: Current issues in molecular biology
Year: 2025, Volume: 47, Issue: 10, Pages: 1-13
ISSN:1467-3045
DOI:10.3390/cimb47100824
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cimb47100824
Verlag, kostenfrei, Volltext: https://www.mdpi.com/1467-3045/47/10/824
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Author Notes:Hadrian Platzer, Alena Bork, Malte Wellbrock, Ghazal Pourbozorg, Simone Gantz, Reza Sorbi, Ravikumar Mayakrishnan, Sébastien Hagmann, Yannic Bangert and Babak Moradi
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Summary:Platelet-rich plasma (PRP) has gained attention in regenerative medicine due to its bio-active proteins with tissue-healing potential. However, heterogeneity in PRP composition remains a major challenge for reproducibility and standardization. Given that body mass index (BMI) affects systemic blood parameters, we investigated whether BMI affects the cellular and molecular composition of PRP. Seventy-three participants were stratified into normal weight, overweight, and obese groups. PRP was prepared using a double-syringe system, and platelet activation was induced by freeze-thaw cycles. Whole blood and PRP cell counts were analyzed, and IL6, IGF1, HGF, and PDGF-BB levels in PRP were quantified by ELISA. Platelet enrichment and levels of IGF1, HGF, and PDGF-BB in PRP did not significantly differ between BMI groups. In contrast, IL6 concentrations were higher in normal-weight compared to overweight and obese individuals. Moreover, BMI-related associations emerged between platelet counts and PDGF-BB, and between PRP proteins and sex or caffeine intake, suggesting a more complex BMI-specific modulation of PRP composition. In conclusion, our findings support considering BMI as a relevant factor in PRP therapy. Incorporating BMI into PRP standardization strategies could improve reproducibility and support personalized regenerative approaches.
Item Description:Veröffentlicht: 8. Oktober 2025
Gesehen am 03.12.2025
Physical Description:Online Resource
ISSN:1467-3045
DOI:10.3390/cimb47100824

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