Buchumschlag

Association between body mass index and the composition of leucocyte-poor platelet-rich plasma: implications for personalized approaches in musculoskeletal medicine

Platelet-rich plasma (PRP) has gained attention in regenerative medicine due to its bio-active proteins with tissue-healing potential. However, heterogeneity in PRP composition remains a major challenge for reproducibility and standardization. Given that body mass index (BMI) affects systemic blood...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Platzer, Hadrian (VerfasserIn) , Bork, Alena (VerfasserIn) , Wellbrock, Malte (VerfasserIn) , Pourbozorg, Ghazal (VerfasserIn) , Gantz, Simone (VerfasserIn) , Sorbi, Reza (VerfasserIn) , Mayakrishnan, Ravikumar (VerfasserIn) , Hagmann, Sébastien (VerfasserIn) , Bangert, Yannic (VerfasserIn) , Moradi, Babak (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 8 October 2025
In: Current issues in molecular biology
Year: 2025, Jahrgang: 47, Heft: 10, Pages: 1-13
ISSN:1467-3045
DOI:10.3390/cimb47100824
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cimb47100824
Verlag, kostenfrei, Volltext: https://www.mdpi.com/1467-3045/47/10/824
Volltext
Verfasserangaben:Hadrian Platzer, Alena Bork, Malte Wellbrock, Ghazal Pourbozorg, Simone Gantz, Reza Sorbi, Ravikumar Mayakrishnan, Sébastien Hagmann, Yannic Bangert and Babak Moradi
Beschreibung
Zusammenfassung:Platelet-rich plasma (PRP) has gained attention in regenerative medicine due to its bio-active proteins with tissue-healing potential. However, heterogeneity in PRP composition remains a major challenge for reproducibility and standardization. Given that body mass index (BMI) affects systemic blood parameters, we investigated whether BMI affects the cellular and molecular composition of PRP. Seventy-three participants were stratified into normal weight, overweight, and obese groups. PRP was prepared using a double-syringe system, and platelet activation was induced by freeze-thaw cycles. Whole blood and PRP cell counts were analyzed, and IL6, IGF1, HGF, and PDGF-BB levels in PRP were quantified by ELISA. Platelet enrichment and levels of IGF1, HGF, and PDGF-BB in PRP did not significantly differ between BMI groups. In contrast, IL6 concentrations were higher in normal-weight compared to overweight and obese individuals. Moreover, BMI-related associations emerged between platelet counts and PDGF-BB, and between PRP proteins and sex or caffeine intake, suggesting a more complex BMI-specific modulation of PRP composition. In conclusion, our findings support considering BMI as a relevant factor in PRP therapy. Incorporating BMI into PRP standardization strategies could improve reproducibility and support personalized regenerative approaches.
Beschreibung:Veröffentlicht: 8. Oktober 2025
Gesehen am 03.12.2025
Beschreibung:Online Resource
ISSN:1467-3045
DOI:10.3390/cimb47100824

Ähnliche Einträge