Buchumschlag

Metabolic dysfunction-associated steatotic liver disease (MASLD) impacts long-term outcomes after curative-intent surgery for hepatocellular carcinoma: original article

Background: Curative surgery for hepatocellular carcinoma (HCC) includes liver resection (LR) and orthotopic liver transplantation (OLT). Due to the obesity epidemic, metabolic dysfunction-associated steatotic liver disease (MASLD) is a frequent HCC aetiology that often coincides with increased alco...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Uluk, Deniz (VerfasserIn) , Pein, Justus (VerfasserIn) , Herda, Sophia (VerfasserIn) , Schliephake, Frederik (VerfasserIn) , Schneider, Carolin V. (VerfasserIn) , Bitar, Jude (VerfasserIn) , Dreher, Katharina (VerfasserIn) , Eurich, Dennis (VerfasserIn) , Zhang, Ingrid W. (VerfasserIn) , Schaffrath, Lukas (VerfasserIn) , Auer, Timo A. (VerfasserIn) , Collettini, Federico (VerfasserIn) , Engelmann, Cornelius (VerfasserIn) , Tacke, Frank (VerfasserIn) , Pratschke, Johann (VerfasserIn) , Lurje, Isabella (VerfasserIn) , Lurje, Georg (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2025
In: Alimentary pharmacology & therapeutics
Year: 2025, Jahrgang: 61, Heft: 8, Pages: 1318-1332
ISSN:1365-2036
DOI:10.1111/apt.70002
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/apt.70002
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/apt.70002
Volltext
Verfasserangaben:Deniz Uluk, Justus Pein, Sophia Herda, Frederik Schliephake, Carolin V. Schneider, Jude Bitar, Katharina Dreher, Dennis Eurich, Ingrid W. Zhang, Lukas Schaffrath, Timo A. Auer, Federico Collettini, Cornelius Engelmann, Frank Tacke, Johann Pratschke, Isabella Lurje, Georg Lurje
Beschreibung
Zusammenfassung:Background: Curative surgery for hepatocellular carcinoma (HCC) includes liver resection (LR) and orthotopic liver transplantation (OLT). Due to the obesity epidemic, metabolic dysfunction-associated steatotic liver disease (MASLD) is a frequent HCC aetiology that often coincides with increased alcohol consumption, termed MetALD, or even alcohol-associated liver disease (ALD). Methods :Patients undergoing LR or OLT for HCC at Charité—Universitätsmedizin Berlin (2010-2020) were included in this retrospective cohort study investigating disease aetiology, time to recurrence (TTR), overall survival (OS) and CT-based body composition. Results Out of 579 patients with HCC, 417 underwent LR and 162 OLT. Tumour aetiologies were viral n = 191 (33.0%), MASLD n = 158 (27.3%), MetALD n = 51 (8.8%), ALD n = 68 (11.7%) and other/cryptogenic n = 111 (19.2%). Patients with MASLD and MetALD had more intramuscular (p < 0.001, p = 0.015) and visceral fat (both p < 0.001) than patients with non-metabolic dysfunction aetiologies. Patients with MASLD-HCC had comparable TTR (median 26 months, [95% CI: 23-31] vs. 30 months [95% CI: 4-57], p = 0.425) but shorter OS than patients with other HCC aetiologies (63 months [95% CI: 42-84] vs. 80 months [95% CI: 60-100], hazard ratio: 1.53 [95% CI: 1.050-2.229], p = 0.026) after LR. Multivariate analysis confirmed MASLD aetiology, portal vein thrombosis and MELD score ≥ 10 as independent prognostic factors for OS in LR (adjusted p = 0.021,p < 0.001,p = 0.003), even after excluding in-hospital mortality (adjusted p = 0.016,p = 0.002,p = 0.002). Causes of death were similar in MASLD and non-MASLD aetiology. Conclusions: Patients with HCC undergoing LR and meeting the new MASLD criteria have significantly shorter OS. This study provides empirical prognostic evidence for the novel MASLD/MetALD classification in a large European cohort of patients undergoing curative-intent HCC therapy.
Beschreibung:Gesehen am 03.12.2025
Beschreibung:Online Resource
ISSN:1365-2036
DOI:10.1111/apt.70002

Ähnliche Einträge