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Emotional maltreatment shapes the relationship between psychosocial functioning and hippocampal structure in schizophrenia spectrum disorders

Background - The hippocampus and amygdala are important limbic structures involved in memory, emotional regulation, and stress response, which are pivotal for social interactions, everyday functioning, and participation in community life. However, the presumably bidirectional relationship between li...

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Hauptverfasser: Akkoc Altinok, Dilsa Cemre (VerfasserIn) , Fritze, Stefan (VerfasserIn) , Volkmer, Sebastian (VerfasserIn) , Brandt, Geva A. (VerfasserIn) , Wölfl, Lana (VerfasserIn) , Kukovic, Jacqueline (VerfasserIn) , Berhe, Oksana (VerfasserIn) , Lin, Yuchen (VerfasserIn) , Tost, Heike (VerfasserIn) , Braun, Urs (VerfasserIn) , Meyer-Lindenberg, Andreas (VerfasserIn) , Hirjak, Dusan (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: November 2025
In: Schizophrenia research
Year: 2025, Jahrgang: 285, Pages: 242-254
ISSN:1573-2509
DOI:10.1016/j.schres.2025.09.031
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.schres.2025.09.031
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0920996425003500
Volltext
Verfasserangaben:Dilsa Cemre Akkoc Altinok, Stefan Fritze, Sebastian Volkmer, Geva A. Brandt, Lana Wölfl, Jacqueline Kukovic, Oksana Berhe, Yuchen Lin, Heike Tost, Urs Braun, Andreas Meyer-Lindenberg, Dusan Hirjak
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Zusammenfassung:Background - The hippocampus and amygdala are important limbic structures involved in memory, emotional regulation, and stress response, which are pivotal for social interactions, everyday functioning, and participation in community life. However, the presumably bidirectional relationship between limbic structure and psychosocial functioning—and the potential moderating role of early-life environmental risk factors—remains poorly understood in schizophrenia spectrum (SSD) and mood disorders (MOD). - Methods - Structural 3 T MRI data were collected from SSD (n = 64) and MOD (n = 66) patients as well as healthy controls (HC, n = 46). Hippocampal subfields and amygdala nuclei were segmented using FreeSurfer v7.3.2. Psychosocial functioning was assessed with the Personal and Social Performance Scale (PSP). Childhood maltreatment, urban upbringing, and migration background were examined as potential moderators. - Results - SSD patients showed significant volume reductions in left hippocampal subfields compared to HC (FDR-corrected p < .05). Within SSD, PSP scores were associated with volumes of the left hippocampal body, tail, and molecular layer (FDR-corrected p < .05), with emotional abuse and neglect significantly moderating these associations. No other environmental risk factors showed significant interaction effects. In MOD, only the left fimbria differed from HC (FDR-corrected p < .05), but this was unrelated to PSP scores, and no significant interactions were found. - Conclusion - Our findings indicate that early-life emotional adversity moderates the relationship between psychosocial functioning and hippocampal structure in SSD, but not in MOD, highlighting the need to consider emotional trauma histories when investigating functional outcomes in SSD patients.
Beschreibung:Online verfügbar: 8. Oktober 2025, Artikelversion: 8. Oktober 2025
Gesehen am 04.12.2025
Beschreibung:Online Resource
ISSN:1573-2509
DOI:10.1016/j.schres.2025.09.031

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