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Follow-up 18F-FDG PET/CT versus contrast-enhanced CT after ablation of liver metastases of colorectal carcinoma: a cost-effectiveness analysis

Purpose: After a percutaneous ablation of colorectal liver metastases (CRLM), follow-up investigations to evaluate potential tumor recurrence are necessary. The aim of this study was to analyze whether a combined 18F-Fluordesoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT...

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Main Authors: Schnitzer, Moritz Ludwig (Author) , Froelich, Matthias F. (Author) , Gassert, Felix (Author) , Huber, Thomas (Author) , Gresser, Eva Kristina (Author) , Schwarze, Vincent (Author) , Nörenberg, Dominik (Author) , Todica, Andrei Stefan (Author) , Rübenthaler, Johannes (Author)
Format: Article (Journal)
Language:English
Published: 27 August 2020
In: Cancers
Year: 2020, Volume: 12, Issue: 9, Pages: 1-14
ISSN:2072-6694
DOI:10.3390/cancers12092432
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers12092432
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/12/9/2432
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Author Notes:Moritz L. Schnitzer, Matthias F. Froelich, Felix G. Gassert, Thomas Huber, Eva Gresser, Vincent Schwarze, Dominik Nörenberg, Andrei Todica and Johannes Rübenthaler
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Summary:Purpose: After a percutaneous ablation of colorectal liver metastases (CRLM), follow-up investigations to evaluate potential tumor recurrence are necessary. The aim of this study was to analyze whether a combined 18F-Fluordesoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT) scan is cost-effective compared to a contrast-enhanced computed tomography (CE-CT) scan for detecting local tumor progression. Materials and Methods: A decision model based on Markov simulations that estimated lifetime costs and quality-adjusted life years (QALYs) was developed. Model input parameters were obtained from the recent literature. Deterministic sensitivity analysis of diagnostic parameters based on a Monte-Carlo simulation with 30,000 iterations was performed. The willingness-to-pay (WTP) was set to $100,000/QALY. Results: In the base-case scenario, CE-CT resulted in total costs of $28,625.08 and an efficacy of 0.755 QALYs, whereas 18F-FDG PET/CT resulted in total costs of $29,239.97 with an efficacy of 0.767. Therefore, the corresponding incremental cost-effectiveness ratio (ICER) of 18F-FDG PET/CT was $50,338.96 per QALY indicating cost-effectiveness based on the WTP threshold set above. The results were stable in deterministic and probabilistic sensitivity analyses. Conclusion: Based on our model, 18F-FDG PET/CT can be considered as a cost-effective imaging alternative for follow-up investigations after percutaneous ablation of colorectal liver metastases.
Item Description:Gesehen am 05.12.2025
Physical Description:Online Resource
ISSN:2072-6694
DOI:10.3390/cancers12092432

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