Follow-up 18F-FDG PET/CT versus contrast-enhanced CT after ablation of liver metastases of colorectal carcinoma: a cost-effectiveness analysis
Purpose: After a percutaneous ablation of colorectal liver metastases (CRLM), follow-up investigations to evaluate potential tumor recurrence are necessary. The aim of this study was to analyze whether a combined 18F-Fluordesoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT...
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
27 August 2020
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| In: |
Cancers
Year: 2020, Jahrgang: 12, Heft: 9, Pages: 1-14 |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers12092432 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers12092432 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/12/9/2432 
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| Verfasserangaben: | Moritz L. Schnitzer, Matthias F. Froelich, Felix G. Gassert, Thomas Huber, Eva Gresser, Vincent Schwarze, Dominik Nörenberg, Andrei Todica and Johannes Rübenthaler |
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| 245 | 1 | 0 | |a Follow-up 18F-FDG PET/CT versus contrast-enhanced CT after ablation of liver metastases of colorectal carcinoma |b a cost-effectiveness analysis |c Moritz L. Schnitzer, Matthias F. Froelich, Felix G. Gassert, Thomas Huber, Eva Gresser, Vincent Schwarze, Dominik Nörenberg, Andrei Todica and Johannes Rübenthaler |
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| 246 | 3 | 3 | |a Follow-up 18 F-FDG PET/CT vs. contrast-enhanced CT after ablation of liver metastases of colorectal carcinoma |
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| 520 | |a Purpose: After a percutaneous ablation of colorectal liver metastases (CRLM), follow-up investigations to evaluate potential tumor recurrence are necessary. The aim of this study was to analyze whether a combined 18F-Fluordesoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT) scan is cost-effective compared to a contrast-enhanced computed tomography (CE-CT) scan for detecting local tumor progression. Materials and Methods: A decision model based on Markov simulations that estimated lifetime costs and quality-adjusted life years (QALYs) was developed. Model input parameters were obtained from the recent literature. Deterministic sensitivity analysis of diagnostic parameters based on a Monte-Carlo simulation with 30,000 iterations was performed. The willingness-to-pay (WTP) was set to $100,000/QALY. Results: In the base-case scenario, CE-CT resulted in total costs of $28,625.08 and an efficacy of 0.755 QALYs, whereas 18F-FDG PET/CT resulted in total costs of $29,239.97 with an efficacy of 0.767. Therefore, the corresponding incremental cost-effectiveness ratio (ICER) of 18F-FDG PET/CT was $50,338.96 per QALY indicating cost-effectiveness based on the WTP threshold set above. The results were stable in deterministic and probabilistic sensitivity analyses. Conclusion: Based on our model, 18F-FDG PET/CT can be considered as a cost-effective imaging alternative for follow-up investigations after percutaneous ablation of colorectal liver metastases. | ||
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