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CisBP-RNA: a web resource for eukaryotic RNA-binding proteins and their motifs

RNA-binding proteins (RBPs) are key mediators of post-transcriptional gene regulation, including splicing, transport, stability, and other facets of RNA metabolism. Many RBPs exert their function through sequence-specific protein-RNA interactions. RBP RNA-binding specificity models, or motifs, are t...

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Main Authors: Rosado-Tristani, Diego (Author) , Albu, Mihai (Author) , Chen, Xiaoting (Author) , Sasse, Alexander (Author) , Laverty, Kaitlin U (Author) , Ray, Debashish (Author) , Tam, Cyrus L (Author) , Ernst, Kevin (Author) , Lawson, Lucinda P (Author) , Morris, Quaid D (Author) , Hughes, Timothy R (Author) , Weirauch, Matthew T (Author)
Format: Article (Journal)
Language:English
Published: 29 October 2025
In: Nucleic acids research
Year: 2025, Pages: 1-8
ISSN:1362-4962
DOI:10.1093/nar/gkaf1081
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1093/nar/gkaf1081
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Author Notes:Diego A. Rosado-Tristani, Mihai Albu, Xiaoting Chen, Alexander Sasse, Kaitlin U. Laverty, Debashish Ray, Cyrus L. Tam, Kevin Ernst, Lucinda P. Lawson, Quaid D. Morris, Timothy R. Hughes, Matthew T. Weirauch
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Summary:RNA-binding proteins (RBPs) are key mediators of post-transcriptional gene regulation, including splicing, transport, stability, and other facets of RNA metabolism. Many RBPs exert their function through sequence-specific protein-RNA interactions. RBP RNA-binding specificity models, or motifs, are thus essential for understanding post-transcriptional gene regulatory mechanisms. Here, we present CisBP-RNA (Catalog of inferred sequence Binding Preferences of RNA-binding proteins), a freely available web-based database that provides centralized access to eukaryotic RBP motif data. A key feature of CisBP-RNA is the availability of both experimentally determined motifs and motifs that are computationally predicted via our homology-based approaches. The current version of CisBP-RNA catalogs >148 000 sequence-specific RBPs across 690 eukaryotic species. Motifs are currently available for >34 000 of these RBPs. Motif data are available for download in a variety of formats for downstream computational analyses. In addition, CisBP-RNA provides user-friendly web-hosted tools to scan for predicted RBP binding sites, predicts motifs for a protein of interest, and compares a motif to motifs contained in the database. The CisBP-RNA database can be accessed through www.cisbp.org/rna/.
Item Description:Veröffentlicht: 29. Oktober 2025
Gesehen am 08.12.2025
Physical Description:Online Resource
ISSN:1362-4962
DOI:10.1093/nar/gkaf1081

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