Spatial and functional dissection of cancer-associated fibroblasts-mediated immune modulation in H. pylori-associated gastric cancer

Cancer-associated fibroblasts (CAFs) are key regulators of the tumor microenvironment, yet their spatial organization and immunomodulatory functions in H. pylori-associated gastric cancer (GC) remain incompletely understood.

Bibliographic Details

Main Authors:	Chen, Bonan (Author) , Tang, Hongzhen (Author) , Zheng, Xiaohong (Author) , Xie, Fuda (Author) , Yu, Peiyao (Author) , Lyu, Yang (Author) , Feng, Tiejun (Author) , Wu, Jialin (Author) , Liu, Jingya (Author) , Xu, Yi (Author) , Cheung, Alvin H. K. (Author) , Fang, Canbin (Author) , Wang, Zhangding (Author) , Wang, Shouyu (Author) , Cheung, Justin Chak Ting (Author) , Dong, Yujuan (Author) , Tian, Ruoxi (Author) , Zhang, Yigan (Author) , Lu, Cheng (Author) , Wong, Chi Chun (Author) , Yu, Jun (Author) , Wu, William K. K. (Author) , Burgermeister, Elke (Author) , Tong, Man (Author) , Zhang, Fengbin (Author) , Kang, Wei (Author) , Leung, Kam Tong (Author) , To, Ka Fai (Author)
Format:	Article (Journal)
Language:	English
Published:	December 2025
In:	Molecular cancer Year: 2025, Volume: 24, Issue: 1, Pages: 1-20
ISSN:	1476-4598
DOI:	10.1186/s12943-025-02490-9
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12943-025-02490-9
Author Notes:	Bonan Chen, Hongzhen Tang, Xiaohong Zheng, Fuda Xie, Peiyao Yu, Yang Lyu, Tiejun Feng, Jialin Wu, Jingya Liu, Yi Xu, Alvin H. K. Cheung, Canbin Fang, Zhangding Wang, Shouyu Wang, Justin Chak Ting Cheung, Yujuan Dong, Ruoxi Tian, Yigan Zhang, Cheng Lu, Chi Chun Wong, Jun Yu, William K. K. Wu, Elke Burgermeister, Man Tong, Fengbin Zhang, Wei Kang, Kam Tong Leung and Ka Fai To