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GPU-accelerated FREDopt package for simultaneous dose and LETd proton radiotherapy plan optimization via superiorization methods

This study presents Fast paRticle thErapy Dose optimizer (FREDopt), a newly developed GPU-accelerated open-source optimization software for simultaneous proton dose and dose-averaged linear energy transfer (LETd) optimization in intensity-modulated proton therapy treatment planning. FREDopt was impl...

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Main Authors: Borys, Damian (Author) , Gajewski, Jan (Author) , Becher, Tobias (Author) , Censor, Yair (Author) , Kopeć, Renata (Author) , Rydygier, Marzena (Author) , Schiavi, Angelo (Author) , Skóra, Tomasz (Author) , Spaleniak, Anna (Author) , Wahl, Niklas (Author) , Wochnik, Agnieszka (Author) , Ruciński, Antoni (Author)
Format: Article (Journal)
Language:English
Published: 1 August 2025
In: Physics in medicine and biology
Year: 2025, Volume: 70, Issue: 15, Pages: 1-16
ISSN:1361-6560
DOI:10.1088/1361-6560/ade841
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1088/1361-6560/ade841
Verlag, kostenfrei, Volltext: https://iopscience.iop.org/article/10.1088/1361-6560/ade841
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Author Notes:Damian Borys, Jan Gajewski, Tobias Becher, Yair Censor, Renata Kopeć, Marzena Rydygier, Angelo Schiavi, Tomasz Skóra, Anna Spaleniak, Niklas Wahl, Agnieszka Wochnik, and Antoni Ruciński
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Summary:This study presents Fast paRticle thErapy Dose optimizer (FREDopt), a newly developed GPU-accelerated open-source optimization software for simultaneous proton dose and dose-averaged linear energy transfer (LETd) optimization in intensity-modulated proton therapy treatment planning. FREDopt was implemented entirely in Python, leveraging CuPy for GPU acceleration and incorporating fast Monte Carlo simulations from the FRED code. The treatment plan optimization workflow includes pre-optimization and optimization, the latter equipped with a novel superiorization of feasibility-seeking algorithms. Feasibility-seeking requires finding a point that satisfies prescribed constraints. Superiorization interlaces computational perturbations into iterative feasibility-seeking steps to steer them toward a superior feasible point, replacing the need for costly full-fledged constrained optimization. The method was validated on two treatment plans of patients treated in a clinical proton therapy center, with dose and LETd distributions compared before and after reoptimization. Simultaneous dose and LETd optimization using FREDopt led to a substantial reduction of LETd and (dose) × (LETd) in organs at risk while preserving target dose conformity. Computational performance evaluation showed execution times of 14-50 min, depending on the algorithm and target volume size—satisfactory for clinical and research applications while enabling further development of the well-tested, documented open-source software.
Item Description:Im Titel ist "d" in LETd untergestellt
Gesehen am 10.12.2025
Physical Description:Online Resource
ISSN:1361-6560
DOI:10.1088/1361-6560/ade841

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