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Community versus institutionalised care for people with severe mental illness in five countries in Southeast Europe: pooled analysis of five randomised trials

Background The RECOVER-E project implemented community-based mental healthcare (CMH) oriented at functional recovery in people with schizophrenia, bipolar and severe major depressive disorder in five countries: Bulgaria, Croatia, Montenegro, North Macedonia and Romania, with the aim to shift care fr...

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Main Authors: Shields-Zeeman, Laura (Author) , Smit, Filip (Author) , Wijnen, Ben (Author) , Roth, Catharina (Author) , Wensing, Michel (Author) , Petrea, Ionela (Author) , Bolinski, Felix (Author) , Bajraktarov, Stojan (Author) , Dedovic, Jovo (Author) , Keet, René (Author) , Kuzman, Martina Rojnic (Author) , Nakov, Vladimir (Author) , Nica, Raluca (Author) , Novotni, Antoni (Author) , Tomcuk, Aleksandar (Author) , Djurisic, Tatjana (Author) , Morales, Guadalupe (Author) , Anghelescu, Tiberiu Rotaru (Author)
Format: Article (Journal)
Language:English
Published: 23 October 2025
In: BMJ global health
Year: 2025, Volume: 10, Issue: 10, Pages: 1-9
ISSN:2059-7908
DOI:10.1136/bmjgh-2024-018594
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1136/bmjgh-2024-018594
Verlag, kostenfrei, Volltext: https://gh.bmj.com/content/10/10/e018594
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Author Notes:Laura Shields-Zeeman, Filip Smit, Ben Wijnen, Catharina Roth, Michel Wensing, Ionela Petrea, on behalf of the RECOVER-E consortium, Felix Bolinski, Stojan Bajraktarov, Jovo Dedovic, René Keet, Martina Rojnic Kuzman, Vladimir Nakov, Raluca Nica, Antoni Novotni, Aleksandar Tomcuk, Tatjana Djurisic, Guadalupe Morales, Tiberiu Rotaru Anghelescu
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Summary:Background The RECOVER-E project implemented community-based mental healthcare (CMH) oriented at functional recovery in people with schizophrenia, bipolar and severe major depressive disorder in five countries: Bulgaria, Croatia, Montenegro, North Macedonia and Romania, with the aim to shift care from institutions to communities.Objective To evaluate the effectiveness of CMH under real-world circumstances across various healthcare ecologies and contexts.Methods A randomised comparison of CMH versus treatment as usual (TAU) based on pooled data from all five RECOVER-E trials (N=931). Outcomes were personal and social role functioning (WHO Disability Assessment Schedule, WHODAS 2.0) and health-related quality of life (EuroQoL-5 Dimensions-3 Levels) at baseline, 12 and 18 months postbaseline. Intention-to-treat analysis was conducted with mixed modelling and a sensitivity analysis adjusted for the impact of COVID-19 on healthcare delivery and outcomes.Findings At 18-month follow-up, CMH had a 4.55 lower WHODAS disability score than TAU, which was significant (b=−4.55, SE=1.21, z=−3.75, p<0.001), and improved quality of life by 0.07 utility (b=0.07, SE=0.014, z=4.56, p<0.001) equivalent to an additional 25 days in full health. Similar effects were observed in each of the five countries and for all WHODAS subdomains (cognition, mobility, self-care, getting along with people, life activities, participation). Sensitivity analyses adjusting for the confounding effect of COVID-19 showed similar effects.Clinical implications Recovery-oriented CMH for people with severe mental illness was effective in improving functioning and quality of life for people with schizophrenia, bipolar disorder and severe depression in five South-Eastern European countries and could be implemented across different health systems.Trial registration numbers Bulgaria: NCT03922425, Croatia: NCT03862209, Macedonia: NCT03892473, Montenegro: NCT03837340, Romania: NCT03884933.
Item Description:Gesehen am 10.12.2025
Physical Description:Online Resource
ISSN:2059-7908
DOI:10.1136/bmjgh-2024-018594

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