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Development and application of an LC-MS/MS method for quantification of fosmidomycin in human and rat plasma

Malaria still poses a significant burden on global health, with millions of cases reported annually and rising resistance to current treatments, emphasizing the need for new therapeutic strategies. Fosmidomycin, initially recognized for its antibacterial properties, has emerged as a promising candid...

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Main Authors: Pfaffendorf, Christoph (Author) , Sackmann, Keanu D. (Author) , Mischlinger, Johannes (Author) , Dejon-Agobé, Jean Claude (Author) , Maïga-Ascofaré, Oumou (Author) , Ahenkan, Ebenezer (Author) , Adegnika, Ayôla Akim (Author) , Ramharter, Michael (Author) , Uhl, Philipp (Author) , Fricker, Gert (Author) , Wicha, Sebastian Georg (Author)
Format: Article (Journal)
Language:English
Published: 25 July 2025
In: Malaria journal
Year: 2025, Volume: 24, Issue: 1, Pages: 1-11
ISSN:1475-2875
DOI:10.1186/s12936-025-05489-1
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12936-025-05489-1
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1186/s12936-025-05489-1
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Author Notes:Christoph Pfaffendorf, Keanu D. Sackmann, Johannes Mischlinger, Jean Claude Dejon-Agobé, Oumou Maïga-Ascofaré, Ebenezer Ahenkan, Ayôla Akim Adegnika, Michael Ramharter, Philipp Uhl, Gert Fricker and Sebastian G. Wicha
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Summary:Malaria still poses a significant burden on global health, with millions of cases reported annually and rising resistance to current treatments, emphasizing the need for new therapeutic strategies. Fosmidomycin, initially recognized for its antibacterial properties, has emerged as a promising candidate in the fight against malaria.
Item Description:Gesehen am 11.12.2025
Physical Description:Online Resource
ISSN:1475-2875
DOI:10.1186/s12936-025-05489-1

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