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Intraoperative radiotherapy in elderly patients with breast cancer: long-term follow-up results of the prospective phase II trial TARGIT-E

Whole-breast radiotherapy (WBRT) after breast-conserving surgery (BCS) in older patients can be challenging due to the increased presence of comorbidities, comedication, the presence of a pacemaker or difficulties in traveling to treatment every day. Challenging times, such as the pandemic, can also...

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Main Authors: Sperk, Elena (Author) , Lemanski, Claire (Author) , Neumaier, Christian (Author) , Lauer, Juliane (Author) , Siefert, Victor (Author) , Völker, Ragna (Author) , Lindner, Christoph (Author) , Niehoff, Peter (Author) , Tallet, Agnes Richard (Author) , Racadot, Séverine (Author) , Petit, Adeline (Author) , Pazos, Montserrat (Author) , Le-Blanc Onfroy, Magali (Author) , Martin, Etienne (Author) , Reuter, Christiane (Author) , Hermann, Robert M. (Author) , Pohl, Fabian (Author) , Friedrichs, Kay (Author) , Würschmidt, Florian (Author) , Pigorsch, Steffi Ulrike (Author) , Kolberg, Hans-Christian (Author) , Graf, Heiko (Author) , Brunner, Thomas B. (Author) , Malter, Wolfram (Author) , Park-Simon, Tjoung-Won (Author) , Brucker, Cosima (Author) , Fleckenstein, Jochen (Author) , Petersen, Cordula (Author) , Tuschy, Benjamin (Author) , Wilken, Eva Ekas (Author) , Büttner, Sylvia (Author) , Sütterlin, Marc (Author) , Flyger, Henrik (Author) , Wenz, Frederik (Author)
Format: Article (Journal)
Language:English
Published: 10 December 2025
In: BMC cancer
Year: 2025, Volume: 25, Pages: 1-10
ISSN:1471-2407
DOI:10.1186/s12885-025-15289-0
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12885-025-15289-0
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Author Notes:Elena Sperk, Claire Lemanski, Christian Neumaier, Juliane Lauer, Victor Siefert, Ragna Völker, Christoph Lindner, Peter Niehoff, Agnes Richard Tallet, Séverine Racadot, Adeline Petit, Montserrat Pazos, Magali Le-Blanc Onfroy, Etienne Martin, Christiane Reuter, Robert Michael Hermann, Fabian Pohl, Kay Friedrichs, Florian Würschmidt, Steffi Pigorsch, Hans-Christian Kolberg, Heiko Graf, Thomas B. Brunner, Wolfram Malter, Tjoung-Wong Park-Simon, Cosima Brucker, Jochen Fleckenstein, Cordula Petersen, Benjamin Tuschy, Eva Ekas Wilken, Sylvia Büttner, Marc Sütterlin, Henrik Flyger and Frederik Wenz
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Summary:Whole-breast radiotherapy (WBRT) after breast-conserving surgery (BCS) in older patients can be challenging due to the increased presence of comorbidities, comedication, the presence of a pacemaker or difficulties in traveling to treatment every day. Challenging times, such as the pandemic, can also lead to RT not being performed despite the indication. Very short treatment regimens are therefor of special interest in this population reducing overall treatment time and radiation exposure. TARGIT-E is a phase II trial investigating intraoperative radiotherapy (IORT) during BCS in elderly patients. We report long-term follow-up results of TARGIT-E.
Item Description:Gesehen am 26.01.2026
Physical Description:Online Resource
ISSN:1471-2407
DOI:10.1186/s12885-025-15289-0

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