Targeting CD276 with Adapter-CAR T-cells provides a novel therapeutic strategy in small cell lung cancer and prevents CD276-dependent fratricide

Survival rates in Small Cell Lung Cancer (SCLC) remain dismal, posing a huge medical need for novel therapies. T-cells, engineered to express chimeric antigen receptors (CAR-T) have demonstrated clinical activity against a variety of haematological malignancies. Yet, efficacy against solid tumour en...

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Bibliographic Details

Main Authors:	Kristmann, Beate (Author) , Werchau, Niels (Author) , Suresh, Lakshmi (Author) , Pezzuto, Elisabeth L. (Author) , Scheuermann, Sophia (Author) , Krost, Simon (Author) , Schilbach, Karin (Author) , Moustafa-Oglou, Moustafa (Author) , Mast, Anna-Sophia (Author) , Droste, Miriam (Author) , Felsberger, André (Author) , Kiefer, Lukas (Author) , Abramowski, Pierre (Author) , Zender, Lars (Author) , Mittelstaet, Joerg (Author) , Seitz, Christian (Author)
Format:	Article (Journal)
Language:	English
Published:	28 July 2025
In:	Journal of hematology & oncology Year: 2025, Volume: 18, Issue: 1, Pages: 1-18
ISSN:	1756-8722
DOI:	10.1186/s13045-025-01729-8
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13045-025-01729-8 Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1186/s13045-025-01729-8?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot&getft_integrator=clarivate
Author Notes:	Beate Kristmann, Niels Werchau, Lakshmi Suresh, Elisabeth L. Pezzuto, Sophia Scheuermann, Simon Krost, Karin Schilbach, Moustafa Moustafa-Oglou, Anna-Sophia Mast, Miriam Droste, André Felsberger, Lukas Kiefer, Pierre Abramowski, Lars Zender, Joerg Mittelstaet and Christian M. Seitz