Decomposing the brain in autism: linking behavioral domains to neuroanatomical variation and genomic underpinnings : archival report
Background - Autism is accompanied by highly individualized patterns of neurodevelopmental differences in brain anatomy. This variability makes the neuroanatomy of autism inherently difficult to describe at the group level. Here, we examined interindividual neuroanatomical differences using a dimens...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
October 2025
|
| In: |
Biological psychiatry. Cognitive neuroscience and neuroimaging
Year: 2025, Volume: 10, Issue: 10, Pages: 1067-1077 |
| ISSN: | 2451-9030 |
| DOI: | 10.1016/j.bpsc.2024.12.003 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.bpsc.2024.12.003 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S2451902224003793 
|
| Author Notes: | Hanna Seelemeyer, Caroline Gurr, Johanna Leyhausen, Lisa M. Berg, Charlotte M. Pretzsch, Tim Schäfer, Bassem Hermila, Christine M. Freitag, Eva Loth, Bethany Oakley, Luke Mason, Jan K. Buitelaar, Christian F. Beckmann, Dorothea L. Floris, Tony Charman, Tobias Banaschewski, Emily Jones, Thomas Bourgeron, on behalf of the EU-AIMS LEAP Group, Declan Murphy, and Christine Ecker |
| Summary: | Background - Autism is accompanied by highly individualized patterns of neurodevelopmental differences in brain anatomy. This variability makes the neuroanatomy of autism inherently difficult to describe at the group level. Here, we examined interindividual neuroanatomical differences using a dimensional approach that decomposed the domains of social communication and interaction (SCI), restricted and repetitive behaviors (RRBs), and atypical sensory processing (ASP) within a neurodiverse study population. Moreover, we aimed to link the resulting neuroanatomical patterns to specific molecular underpinnings. - Methods - Neurodevelopmental differences in cortical thickness (CT) and surface area (SA) were correlated with SCI, RRB, and ASP domain scores by regression of a general linear model in a large neurodiverse sample of 288 autistic individuals and 140 nonautistic individuals, ages 6 to 30 years, recruited within the European Autism Interventions Longitudinal European Autism Project (EU-AIMS LEAP). The domain-specific patterns of neuroanatomical variability were subsequently correlated with cortical gene expression profiles via the Allen Human Brain Atlas. - Results - Across groups, behavioral variations in SCI, RRBs, and ASP were associated with interindividual differences in CT and SA in partially non-overlapping frontoparietal, temporal, and occipital networks. These domain-specific imaging patterns were enriched for genes that 1) are differentially expressed in autism, 2) mediate typical brain development, and 3) are associated with specific cortical cell types. Many of these genes were implicated in pathways governing synaptic structure and function. - Conclusions - Our study corroborates the close relationship between neuroanatomical variation and interindividual differences in autism-related symptoms and traits within the general framework of neurodiversity and links domain-specific patterns of neuroanatomical differences to putative molecular underpinnings. |
|---|---|
| Item Description: | Mitglieder der EU-AIMS LEAP Group: Jumana Ahmad, Sara Ambrosino, Bonnie Auyeung, Tobias Banaschewski, Simon Baron-Cohen, Sarah Baumeister, Christian F. Beckmann, Sven Bölte, Thomas Bourgeron, Carsten Bours, Michael Brammer, Daniel Brandeis, Claudia Brogna, Yvette de Bruijn, Jan K. Buitelaar, Bhismadev Chakrabarti, Tony Charman, Ineke Cornelissen, Daisy Crawley, Flavio Dell'Acqua, Guillaume Dumas, Sarah Durston, Christine Ecker, Jessica Faulkner, Vincent Frouin, Pilar Garcés, David Goyard, Lindsay Ham, Hannah Hayward, Joerg Hipp, Rosemary Holt, Mark H. Johnson, Emily J.H. Jones, Prantik Kundu, Meng-Chuan Lai, Xavier Liogier D'ardhuy, Michael V. Lombardo, Eva Loth, David J. Lythgoe, René Mandl, Andre Marquand, Luke Mason, Maarten Mennes, Andreas Meyer-Lindenberg, Carolin Moessnang, Nico Bast, Declan G.M. Murphy, Bethany Oakley, Laurence O'Dwyer, Marianne Oldehinkel, Bob Oranje, Gahan Pandina, Antonio M. Persico, Barbara Ruggeri, Amber Ruigrok, Jessica Sabet, Roberto Sacco, Antonia San José Cáceres, Emily Simonoff, Will Spooren, Julian Tillmann, Roberto Toro, Heike Tost, Jack Waldman, Steve C.R. Williams, Caroline Wooldridge, Marcel P. Zwiers Online verfügbar: 17. Dezember 2024, Artikelversion: 6. Oktober 2025 Gesehen am 16.12.2025 |
| Physical Description: | Online Resource |
| ISSN: | 2451-9030 |
| DOI: | 10.1016/j.bpsc.2024.12.003 |