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Five doubly unsaturated metabolites of valproic acid in urine and plasma of patients on valproic acid therapy

The urine and plasma of epileptic patients receiving therapeutic doses of valproic acid (2-propyl- pentanoic acid) was found to contain five doubly unsaturated metabolites of valproic acid, which were identified as their trimethylsilyl derivatives by GC/MS. A series of reference substances was synth...

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Bibliographic Details
Main Authors: Kochen, Walter (Author) , Sprunck, H P (Author) , Tauscher, Bernhard (Author) , Klemens, Maria (Author)
Format: Article (Journal)
Language:English
Published: 1984
In: Journal of clinical chemistry and clinical biochemistry
Year: 1984, Volume: 22, Issue: 4, Pages: 309-317
DOI:10.1515/cclm.1984.22.4.309
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1515/cclm.1984.22.4.309
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Author Notes:by W. Kochen, H.P. Sprunck, Klinik der Universität Heidelberg, Kinderklinik, B. Tauscher and M. Klemens, Organisch-Chemisches Institut der Universität Heidelberg
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Summary:The urine and plasma of epileptic patients receiving therapeutic doses of valproic acid (2-propyl- pentanoic acid) was found to contain five doubly unsaturated metabolites of valproic acid, which were identified as their trimethylsilyl derivatives by GC/MS. A series of reference substances was synthesized but only two of them were identical with native metabolites: 2(2-propenyl)-4-pentenoic acid (= 4.4'-diene) and E-2-propyl-2.4- pentadienoic acid (E-2.4-diene). The mass-spectra of the five native metabolites are given. Preliminary quantitative data obtained from four groups of patients indicate increased formation of doubly unsaturated metabolites when valproic acid-induced side-effects are present, and in cases of fatal hepatic failure. The 4.4'-diene has hitherto been found only in fatal cases with hepatic injury. Quantitative data are presented as % of the sum of valproic acid plus all its detected metabolites.
Item Description:Gesehen am 16.12.2025
Physical Description:Online Resource
DOI:10.1515/cclm.1984.22.4.309

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