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International survey-based assessment of the reliability, validity, and interpretability of the TDN grade for neurosurgical adverse events

Neurosurgical adverse events (AE) are frequent and may have dramatic consequences on quality of life. The lack of a standardized classification of their severity hinders evaluation and improvement of the safety of procedures. The Therapy-Disability-Neurology (TDN) grade, validated in 2021 on 6071 in...

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Main Authors: Terrapon, Alexis (Author) , Kälin, Vincens (Author) , Zeitlberger, Anna Maria (Author) , Weller, Jonathan (Author) , Kissling, Cédric (Author) , Neidert, Nicolas (Author) , Mohme, Malte (Author) , El-Garci, Ahmed (Author) , Juratli, Tareq A. (Author) , Dao Trong, Huy Philip (Author) , Stienen, Martin N. (Author) , Hostettler, Isabel Charlotte (Author) , Broggi, Morgan (Author) , Sarnthein, Johannes (Author) , Regli, Luca (Author) , Bozinov, Oliver (Author) , Neidert, Marian Christoph (Author)
Format: Article (Journal)
Language:English
Published: 28 October 2025
In: Scientific reports
Year: 2025, Volume: 15, Pages: 1-11
ISSN:2045-2322
DOI:10.1038/s41598-025-21065-8
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41598-025-21065-8
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41598-025-21065-8
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Author Notes:Alexis Paul Romain Terrapon, Vincens Kälin, Anna Maria Zeitlberger, Jonathan Weller, Cédric Kissling, Nicolas Neidert, Malte Mohme, Ahmed El-Garci, Tareq A. Juratli, Philip Dao Trong, Martin N. Stienen, Isabel Charlotte Hostettler, Morgan Broggi, Johannes Sarnthein, Luca Regli, Oliver Bozinov, Marian Christoph Neidert & TDN Study Group
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Summary:Neurosurgical adverse events (AE) are frequent and may have dramatic consequences on quality of life. The lack of a standardized classification of their severity hinders evaluation and improvement of the safety of procedures. The Therapy-Disability-Neurology (TDN) grade, validated in 2021 on 6071 interventions, overcomes limitations of previous grading-systems by addressing the severity of neurologic and disabling AEs. The aim of the current study is to assess the reliability, validity and applicability of the TDN grade. We conducted an online survey involving participants with varying levels of neurosurgical expertise. Participants assessed the TDN grade for 16 case vignettes and reviewed the validity, interpretability, logicality, simplicity, and usefulness of the grading-system. The TDN grade showed substantial inter-rater (α = 0.66) and intra-rater (α = 0.79) reliability. Most participants recommended reporting its separate dimensions, which demonstrated substantial to almost perfect reliability (inter-rater: α = 0.74; intra-rater: α = 0.85). Online calculation tools significantly improved agreement and participants’ scores. The TDN grade was considered fairly useful, very logical, fairly simple to use and interpret, and its separate dimensions were considered a very valid measure of the severity of AEs. Neurosurgical AEs should be systematically reported, and surveyed neurosurgeons recommend the use of the TDN grade along its separate dimensions for this purpose.
Item Description:Veröffentlicht: 28. Oktober 2025
Gesehen am 02.01.2026
Physical Description:Online Resource
ISSN:2045-2322
DOI:10.1038/s41598-025-21065-8

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