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Initial characterization of the SAFIR prototype PET-MR scanner

The SAFIR collaboration is currently developing a high-rate positron emission tomography (PET) insert to study fast kinetic processes in small animals. Our insert is designed for simultaneous image acquisition with a preclinical 7 T magnetic resonance (MR) imaging device. In contrast to existing pre...

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Main Authors: Ritzer, Christian Edwin (Author) , Becker, Robert (Author) , Buck, Alfred (Author) , Commichau, Volker (Author) , Debus, Jan (Author) , Djambazov, Lubomir (Author) , Eleftheriou, Afroditi (Author) , Fischer, Jannis Nikolaus Rudolf (Author) , Fischer, Peter (Author) , Ito, Mikiko (Author) , Khateri, Parisa (Author) , Lustermann, Werner (Author) , Ritzert, Michael (Author) , Röser, Ulf (Author) , Rudin, Markus (Author) , Sacco, Ilaria (Author) , Tsoumpas, Charalampos (Author) , Warnock, Geoffrey (Author) , Wyss, Matthias (Author) , Zagozdzinska-Bochenek, Agnieszka (Author) , Weber, Bruno (Author) , Dissertori, Günther (Author)
Format: Article (Journal)
Language:English
Published: September 2020
In: IEEE transactions on radiation and plasma medical sciences
Year: 2020, Volume: 4, Issue: 5, Pages: 613-621
ISSN:2469-7311
DOI:10.1109/TRPMS.2020.2980072
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1109/TRPMS.2020.2980072
Verlag, kostenfrei, Volltext: https://ieeexplore.ieee.org/document/9040649/authors
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Author Notes:Christian Ritzer, Robert Becker, Alfred Buck, Volker Commichau, Jan Debus, Lubomir Djambazov, Afroditi Eleftheriou, Jannis Fischer, Peter Fischer, Mikiko Ito, Parisa Khateri, Werner Lustermann, Michael Ritzert, Ulf Röser, Markus Rudin, Ilaria Sacco, Charalampos Tsoumpas, Geoffrey Warnock, Matthias Wyss, Agnieszka Zagozdzinska-Bochenek, Bruno Weber, and Günther Dissertori
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Summary:The SAFIR collaboration is currently developing a high-rate positron emission tomography (PET) insert to study fast kinetic processes in small animals. Our insert is designed for simultaneous image acquisition with a preclinical 7 T magnetic resonance (MR) imaging device. In contrast to existing preclinical PET scanners and inserts, our hardware is optimized for high-rate measurements with source activities up to 500 MBq. As a first step, the SAFIR Prototype insert was constructed. This already incorporates the final components, but has a reduced axial field-of-view (35.6 mm). We use lutetiumyttrium oxyorthosilicate crystals (2.12 mm × 2.12 mm × 13 mm) one-to-one coupled to silicon photomultipliers. All analog signals are digitized within the insert. We use 49 MR-compatible dc- dc converters in the insert to provide the power to all readout electronics. After shimming, no degradation of the homogeneity of the static B0 field in the MR scanner was observed. During full operation, we saw a minor reduction in the signal-to-noise ratio of the MR data of 4.9%. With a low activity point source (22Na 0.65 MBq) we obtained a coincidence energy resolution of 13.8% full width at half maximum (FWhM) and a coincidence timing resolution of 194 ps (FWhM). First PET/MR rat brain and high-rate mouse cardiac images (84.9 MBq) are shown in this article.
Item Description:Gesehen am 02.01.2026
Physical Description:Online Resource
ISSN:2469-7311
DOI:10.1109/TRPMS.2020.2980072

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