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Perioperative blood transfusion is a predictor of acute and chronic renal function deterioration after partial and radical nephrectomy for renal cell carcinoma

Introduction: The aim was to evaluate the impact of perioperative blood transfusions (PBTs) on renal function after surgery for renal cell carcinoma (RCC). Methods: Consecutive patients with RCC who underwent partial nephrectomy or radical nephrectomy between 2005 and 2015 at a tertiary care center...

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Main Authors: Mühlbauer, Julia (Author) , Gilde, Johannes de (Author) , Müller-Steinhardt, Michael (Author) , Porubský, Štefan (Author) , Walach, Margarete (Author) , Nuhn, Philipp (Author) , Klüter, Harald (Author) , Wagener, Nina (Author) , Kriegmair, Maximilian (Author)
Format: Article (Journal)
Language:English
Published: September 2020
In: Urologia internationalis
Year: 2020, Volume: 104, Issue: 9/10, Pages: 775-780
ISSN:1423-0399
DOI:10.1159/000509206
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000509206
Verlag, lizenzpflichtig, Volltext: https://karger.com/uin/article/104/9-10/775/305870/Perioperative-Blood-Transfusion-Is-a-Predictor-of
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Author Notes:Julia Mühlbauer, Johannes de Gilde, Michael Mueller-Steinhardt, Stefan Porubsky, Margarete Walach, Philipp Nuhn, Harald Klüter, Nina Wagener, Maximilian C. Kriegmair
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Summary:Introduction: The aim was to evaluate the impact of perioperative blood transfusions (PBTs) on renal function after surgery for renal cell carcinoma (RCC). Methods: Consecutive patients with RCC who underwent partial nephrectomy or radical nephrectomy between 2005 and 2015 at a tertiary care center were included. Minimum follow-up period was 6 months. A PBT was defined as the transfusion of packed erythrocyte concentrate (EC) within 7 days before until 30 days after surgery. The multivariable analyses were carried out by Cox regression. Results: The overall cohort included 851 patients, of whom 93 (10.9%) received a PBT. The median follow-up was 46 months (range 28-72). In case of a PBT, a median of 2 EC was transfused. PBT patients were older and had a poorer performance status and more comorbidities as well as locally more advanced or metastatic tumors. In the multivariable analyses, PBT was an independent prognostic factor for acute as well as chronic renal impairment (hazard ratio (HR) 2.72, 95% confidence interval (95% CI) 1.45-5.10, p = 0.002 and HR 2.23, 95% CI 1.26-3.70, p = 0.007). Conclusion: PBT is associated with acute and chronic deterioration of kidney function after surgery for RCC. Thus, it may be used to identify patients requiring close nephrological monitoring.
Item Description:Online publiziert: 28. Juli 2020
Gesehen am 05.01.2026
Physical Description:Online Resource
ISSN:1423-0399
DOI:10.1159/000509206

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