Off-label drug use in children and adolescents treated with antidepressants and antipsychotics: results from a prospective multicenter trial

Off-label psychopharmacologic medication use is widespread in child and adolescent psychiatry, but little is known about its associated factors. This study aimed to assess frequency and determinants of off-label use of antidepressants and antipsychotics in youths in daily clinical practice.

Bibliographic Details

Main Authors:	Taurines, Regina (Author) , Gerlach, Manfred (Author) , Correll, Christoph U. (Author) , Plener, Paul L. (Author) , Malzahn, Uwe (Author) , Heuschmann, Peter (Author) , Scherf-Clavel, Maike (Author) , Rock, Hans (Author) , Briegel, Wolfgang (Author) , Fleischhaker, Christian (Author) , Häge, Alexander (Author) , Hellenschmidt, Tobias (Author) , Imgart, Hartmut (Author) , Kaess, Michael (Author) , Karwautz, Andreas (Author) , Kölch, Michael (Author) , Reitzle, Karl (Author) , Renner, Tobias J. (Author) , Reuter-Dang, Su-Yin (Author) , Rexroth, Christian (Author) , Schulte-Körne, Gerd (Author) , Theisen, Frank (Author) , Tini, Elvira (Author) , Wewetzer, Christoph (Author) , Fekete, Stefanie (Author) , Romanos, Marcel (Author) , Egberts, Karin M. (Author)
Format:	Article (Journal)
Language:	English
Published:	December 2025
In:	Child and adolescent psychiatry and mental health Year: 2025, Volume: 19, Issue: 1, Pages: 1-16
ISSN:	1753-2000
DOI:	10.1186/s13034-025-00957-7
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13034-025-00957-7
Author Notes:	Regina Taurines, Manfred Gerlach, Christoph U. Correll, Paul L. Plener, Uwe Malzahn, Peter Heuschmann, Maike Scherf-Clavel, Hans Rock, Wolfgang Briegel, Christian Fleischhaker, Alexander Häge, Tobias Hellenschmidt, Hartmut Imgart, Michael Kaess, Andreas Karwautz, Michael Kölch, Karl Reitzle, Tobias J. Renner, Su-Yin Reuter-Dang, Christian Rexroth, Gerd Schulte-Körne, Frank Theisen, Elvira Tini, Christoph Wewetzer, Stefanie Fekete, Marcel Romanos and Karin M. Egberts