Advanced HyperSight imaging for patients with adaptive SBRT of prostate cancer: a longitudinal analysis of tissue demarcation

Cone-beam computed tomography (CBCT)-based adaptive radiotherapy (ART) at the Ethos® linear accelerator (eLinac) allows for daily anatomical and dosimetric adjustments and relies on robust image quality. This study evaluated the longitudinal image quality of the novel HyperSightTM-CBCT (hCBCT) compa...

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Main Authors: Schmidt, Ralf (Author) , Nguyen, Thien Thanh (Author) , Bicu, Alicia Simone (Author) , Cvachovec, Paula (Author) , Siefert, Victor (Author) , Eckl, Miriam (Author) , Willam, Marvin (Author) , Froelich, Matthias F. (Author) , Schönberg, Stefan (Author) , Ehmann, Michael (Author) , Bürgy, Daniel (Author) , Clausen, Sven (Author) , Fleckenstein, Jens (Author) , Giordano, Frank Anton (Author) , Boda-Heggemann, Judit (Author) , Dreher, Constantin (Author)
Format: Article (Journal)
Language:English
Published: December 2025
In: Radiation oncology
Year: 2025, Volume: 20, Issue: 1, Pages: 1-15
ISSN:1748-717X
DOI:10.1186/s13014-025-02730-8
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13014-025-02730-8
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Author Notes:Ralf Schmidt, Thanh Nguyen, Alicia S. Bicu, Paula Cvachovec, Victor Siefert, Miriam Eckl, Marvin Willam, Matthias F. Froelich, Stefan O. Schoenberg, Michael Ehmann, Daniel Buergy, Sven Clausen, Jens Fleckenstein, Frank A. Giordano, Judit Boda-Heggemann and Constantin Dreher
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Summary:Cone-beam computed tomography (CBCT)-based adaptive radiotherapy (ART) at the Ethos® linear accelerator (eLinac) allows for daily anatomical and dosimetric adjustments and relies on robust image quality. This study evaluated the longitudinal image quality of the novel HyperSightTM-CBCT (hCBCT) compared to planning CT (pCT), using phantoms and data of prostate cancer patients undergoing adaptive stereotactic body radiotherapy (SBRT). Building on this, the longitudinal contour sharpness of the organs in fractional hCBCT and their usability for ART workflow across fractions was evaluated.
Item Description:Online veröffentlicht: 16. Oktober 2025
Gesehen am 08.01.2026
Physical Description:Online Resource
ISSN:1748-717X
DOI:10.1186/s13014-025-02730-8