(R)-Ketamine reduces alcohol intake and alcohol seeking induced by reconsolidation of alcohol-related memories in female Marchigian Sardinian alcohol-preferring rats
Alcohol use disorder (AUD) represents a significant medical challenge, with available therapeutic approaches having limited efficacy. Emerging data suggest that psychedelic compounds could represent an alternative treatment for AUD. Among this class of molecules, ketamine, a dissociative psychedelic...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 November 2025
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| In: |
Psychopharmacology
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| ISSN: | 1432-2072 |
| DOI: | 10.1007/s00213-025-06964-y |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00213-025-06964-y
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| Author Notes: | Elisabetta Ciccocioppo, Sara Massetti, Marcus W. Meinhardt, Fabio Fumagalli, Patrizia Romualdi, Marisa Roberto, Rainer Spanagel, Roberto Ciccocioppo, Esi Domi |
| Summary: | Alcohol use disorder (AUD) represents a significant medical challenge, with available therapeutic approaches having limited efficacy. Emerging data suggest that psychedelic compounds could represent an alternative treatment for AUD. Among this class of molecules, ketamine, a dissociative psychedelic, shows promising properties. It reduces alcohol drinking in rodents and in humans it is used to treat depression, a condition often comorbid with AUD. Unfortunately, the marked dissociative and anesthetic effects of this molecule severely limit its therapeutic application. Ketamine is a racemic mixture of (S, R)-enantiomers, and the R-enantiomer possesses lower dissociative and anesthetic properties compared to the racemic mixture. |
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| Item Description: | Gesehen am 12.01.2026 |
| Physical Description: | Online Resource |
| ISSN: | 1432-2072 |
| DOI: | 10.1007/s00213-025-06964-y |