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Targeting VCAM-1 with chimeric antigen receptor and regulatory T cell for abdominal aortic aneurysm treatment

Abdominal aortic aneurysm (AAA) is a life-threatening condition characterized by the dilation of the abdominal aorta, leading to a high risk of rupture. Current treatment options are limited, particularly for patients ineligible for surgical interventions. This study explores a novel immunotherapeut...

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Main Authors: Gang, Qingwei (Author) , Lun, Yu (Author) , Zhang, Xiaoxu (Author) , Uzokov, Jamol (Author) , Jiang, Han (Author) , He, Yuchen (Author) , Shen, Shikai (Author) , Wang, Shiyue (Author) , Erhart, Philipp (Author) , Böckler, Dittmar (Author) , Li, Yuemeng (Author) , Han, Yanshuo (Author) , Zhang, Jian (Author)
Format: Article (Journal)
Language:English
Published: 15 August 2025
In: Communications biology
Year: 2025, Volume: 8, Pages: 1-16
ISSN:2399-3642
DOI:10.1038/s42003-025-08604-9
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s42003-025-08604-9
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s42003-025-08604-9
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Author Notes:Qingwei Gang, Yu Lun, Xiaoxu Zhang, Jamol Uzokov, Han Jiang, Yuchen He, Shikai Shen, Shiyue Wang, Philipp Erhart, Dittmar Böckler, Yuemeng Li, Yanshuo Han & Jian Zhang
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Summary:Abdominal aortic aneurysm (AAA) is a life-threatening condition characterized by the dilation of the abdominal aorta, leading to a high risk of rupture. Current treatment options are limited, particularly for patients ineligible for surgical interventions. This study explores a novel immunotherapeutic approach using chimeric antigen receptor Treg cells targeting vascular cell adhesion molecule-1 (VCAM-1) to mitigate AAA progression. By leveraging the specificity and regulatory function of CAR-Treg cells, our research aims to modulate the immune response and reduce inflammation in the aneurysmal wall. Results from preclinical mouse models demonstrated that CAR-Treg cells effectively homed to the aneurysmal site, suppressed local inflammation, and decreased aortic dilation compared to control groups. These findings suggest that CAR-Treg cell therapy could provide a promising, non-surgical treatment option for AAA patients, addressing a critical unmet need in cardiovascular disease management.
Item Description:Veröffentlicht: 15. August 2025
Gesehen am 13.01.2026
Physical Description:Online Resource
ISSN:2399-3642
DOI:10.1038/s42003-025-08604-9

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