Clinical impact of obsessive-compulsive disorder comorbidity in bipolar disorder: a systematic review and meta-analysis : OCD in BD: a review on clinical impact : review/meta-analysis
BackgroundBipolar disorder (BD) is commonly comorbid with other psychiatric conditions, such as obsessive-compulsive disorder (OCD). Despite increasing interest in this comorbidity, quantitative data on its clinical characteristics remain limited. This systematic review and meta-analysis aimed to ev...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
26 August 2025
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| In: |
European psychiatry
Year: 2025, Volume: 68, Issue: 1, Pages: 1-13 |
| ISSN: | 1778-3585 |
| DOI: | 10.1192/j.eurpsy.2025.10087 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1192/j.eurpsy.2025.10087 Verlag, kostenfrei, Volltext: https://www.cambridge.org/core/journals/european-psychiatry/article/clinical-impact-of-obsessivecompulsive-disorder-comorbidity-in-bipolar-disorder-a-systematic-review-and-metaanalysis/CD6BD510A6B1E4D524F7622FD3025070 
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| Author Notes: | Michele De Prisco, Cristiana Tapoi, Vincenzo Oliva, Robertas Strumila, Christine Takami, Nicolaja Girone, Monica Macellaro, Juliana Braga de Salles Andrade, Christian Nikolaus Schmitz, Eduard Vieta and Giovanna Fico |
| Summary: | BackgroundBipolar disorder (BD) is commonly comorbid with other psychiatric conditions, such as obsessive-compulsive disorder (OCD). Despite increasing interest in this comorbidity, quantitative data on its clinical characteristics remain limited. This systematic review and meta-analysis aimed to evaluate the clinical impact of OCD comorbidity in BD by comparing individuals with BD and OCD (BD-OCD) to those with BD without OCD.MethodsWe systematically searched the PubMed/MEDLINE, Scopus, PsycINFO, and Web of Science databases up to April 15, 2024. Meta-analyses were conducted to compare BD-OCD and BD without OCD groups across multiple clinical domains.ResultsFrom 11,959 initial records screened, 26 studies were included in the qualitative synthesis, with 22 eligible for meta-analysis. Individuals with BD-OCD showed higher odds of experiencing chronic mood episodes (OR = 9.42; 95%CI = 2.23, 39.9), rapid cycling (OR = 1.92; 95%CI = 1.04, 3.53), comorbid eating disorders (OR = 3.37; 95%CI = 1.99, 5.7), panic disorder (OR = 3.3; 95%CI = 2.11, 5.2), substance use disorders (OR = 1.39; 95%CI = 1.02, 1.89), and lifetime suicide attempts (OR = 1.85; 95%CI = 1.21, 2.84). Additionally, they presented earlier onset of BD (SMD = -0.27; 95%CI = -0.52, −0.01) and reduced functioning (SMD = -0.42; 95%CI = -0.59, −0.24). Most data were derived from adult populations, limiting the evidence available for children and adolescents.ConclusionsBD-OCD presents a more severe and complex clinical profile, requiring specialized assessment and integrated treatment approaches. Identifying these features may support earlier recognition and inform personalized interventions for this population. |
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| Item Description: | Gesehen am 15.01.2026 |
| Physical Description: | Online Resource |
| ISSN: | 1778-3585 |
| DOI: | 10.1192/j.eurpsy.2025.10087 |