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iPSC line DHMCi010-A is derived from a hereditary nephrotic syndrome patient with an autosomal recessive NPHS2 mutation

Recessive mutations in the NPHS2 gene, encoding the podocyte membrane protein podocin, are the most common genetic cause of childhood-onset nephrotic syndrome. To generate induced pluripotent stem cells (iPSCs), peripheral blood mononuclear cells (PBMCs) from a male patient with a homozygous NPHS2 m...

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Bibliographische Detailangaben
Hauptverfasser: Matthes, Robert (VerfasserIn) , Tabatabaeifar, Mansoureh (VerfasserIn) , Burau, Karin (VerfasserIn) , Schaefer, Franz (VerfasserIn) , Jung-Klawitter, Sabine (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 14 September 2025
In: Stem cell research
Year: 2025, Jahrgang: 88, Pages: 1-5
ISSN:1876-7753
DOI:10.1016/j.scr.2025.103836
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.scr.2025.103836
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1873506125001862
Volltext
Verfasserangaben:Robert Matthes, Mansoureh Tabatabaeifar, Karin Burau, Franz Schaefer, Sabine Jung-Klawitter
Beschreibung
Zusammenfassung:Recessive mutations in the NPHS2 gene, encoding the podocyte membrane protein podocin, are the most common genetic cause of childhood-onset nephrotic syndrome. To generate induced pluripotent stem cells (iPSCs), peripheral blood mononuclear cells (PBMCs) from a male patient with a homozygous NPHS2 mutation (c.413G>A(;)(c.413G>A)) were reprogrammed using the Cytotune®-iPSC 2.0 Sendai Reprogramming Kit (Invitrogen). The resulting iPSCs exhibit normal morphology and karyotype, express undifferentiated hPSC state markers, and demonstrate the capacity for spontaneous differentiation into all three germ layers in vitro.
Beschreibung:Gesehen am 15.01.2026
Beschreibung:Online Resource
ISSN:1876-7753
DOI:10.1016/j.scr.2025.103836

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